CELSR2
CELSR2 (cadherin EGF LAG seven-pass G-type receptor 2) is a seven-pass transmembrane receptor of the flamingo subfamily of the cadherin superfamily. Also known as Flamingo1, KIAA0279, MEGF3, CDHF10, ADGRC2 and EGFL2, it may contribute to cell-cell signalling during nervous system formation. Browse Assay Genie's current range of CELSR2 research reagents below, or read on for the biology behind the target.
CELSR2 is a receptor that may have an important role in cell-to-cell signalling during nervous system formation. It belongs to the flamingo subfamily, part of the cadherin superfamily. Flamingo cadherins are non-classic cadherins, a subpopulation that does not interact with catenins. They are postulated to act as receptors in contact-mediated communication, with cadherin domains serving as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions.
The CELSR2 protein sits at the plasma membrane. Its ectodomain contains nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats, and it spans the membrane seven times, a feature unique to the flamingo subfamily. UniProt places it in the G protein-coupled receptor 2 family, LN-TM7 subfamily. HGNC classifies the CELSR2 gene within the adhesion G protein-coupled receptors, subfamily C, and the CELSR cadherins. Mouse and rat both have a Celsr2 ortholog.
The gene has appeared under several names, including cadherin, EGF LAG seven-pass G-type receptor 2, flamingo (Drosophila) homolog, as well as KIAA0279, MEGF3, Flamingo1, CDHF10, ADGRC2 and EGFL2. The specific function of this family member has not been fully determined, so CELSR2 remains an open subject for work on adhesion receptors and neural development.
CELSR2 may have an important role in cell-cell signalling during nervous system formation, making it relevant to studies of neural development.
As a member of adhesion G protein-coupled receptors subfamily C, CELSR2 is useful for studying seven-transmembrane receptors that combine adhesion and signalling features.
Flamingo cadherins are non-classic cadherins that do not interact with catenins, offering a contrast with classical cadherin adhesion mechanisms.
Flamingo cadherins are postulated receptors in contact-mediated communication, with cadherin domains acting as homophilic binding regions.
CELSR2 is a receptor that may have an important role in cell-cell signalling during nervous system formation. Flamingo cadherins are postulated to mediate contact-mediated communication, but the specific function of this particular member has not been determined.
CELSR2 is also called Flamingo1, KIAA0279, MEGF3, CDHF10, ADGRC2 and EGFL2. Earlier names include cadherin, EGF LAG seven-pass G-type receptor 2, flamingo (Drosophila) homolog. The ADGRC2 symbol reflects its place among adhesion GPCRs.
Yes. The gene has orthologs named Celsr2 in both mouse and rat, and the name refers to the Drosophila flamingo homolog. Check the datasheet of any product for its validated reactivity.
Other CELSR cadherin family members and related adhesion receptors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9HCU4; product specifications from Assay Genie datasheets.