CORO1A
CORO1A (coronin 1A) is a WD repeat protein of the coronin family that is thought to be a crucial component of the cytoskeleton in highly motile cells. It is also known as HCORO1, p57 and coronin-1. Browse Assay Genie's current range of CORO1A research reagents below, or read on for the biology behind the target.
CORO1A may be a crucial component of the cytoskeleton of highly motile cells. It is proposed to function both in the invagination of large pieces of plasma membrane and in forming the plasma membrane protrusions involved in cell locomotion. In cells infected with mycobacteria, CORO1A is retained on the phagosomal membrane, and this retention prevents fusion between phagosomes and lysosomes.
The CORO1A gene encodes a member of the WD repeat protein family, and the protein belongs to the WD repeat coronin family. WD repeats are minimally conserved regions of approximately 40 amino acids, typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate the formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis and gene regulation. In the HGNC classification, CORO1A sits in the WD repeat domain containing group and the coronins group. UniProt records the protein in the cytoplasm, at the cytoskeleton and cell cortex, and at the phagosome membrane.
Alternative splicing of the CORO1A gene results in multiple transcript variants, and a related pseudogene has been defined on chromosome 16. The protein was originally named coronin, actin-binding protein, 1A, and the symbols HCORO1 and p57 are still used in the literature. Mouse and rat each have a Coro1a ortholog, which allows the biology of the CORO1A gene to be studied in rodent systems. A related family member, CORO1C, is also a subject of research.
CORO1A is proposed to support cytoskeletal remodelling and plasma membrane protrusions in highly motile cells, making it a candidate for studies of cell locomotion.
The protein is implicated in the invagination of large pieces of plasma membrane and is found on the phagosome membrane.
Retention of CORO1A on the phagosomal membrane in infected cells prevents phagosome-lysosome fusion, a mechanism relevant to host-pathogen studies.
As a WD repeat coronin, CORO1A is used to explore how WD repeat domains may mediate multiprotein complex formation.
CORO1A may be a crucial component of the cytoskeleton of highly motile cells. It is proposed to act in plasma membrane invagination and in forming protrusions involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents phagosome-lysosome fusion.
CORO1A stands for coronin 1A, and the protein is called Coronin-1A in UniProt. Aliases include HCORO1, p57 and coronin-1. The earlier HGNC name was coronin, actin-binding protein, 1A. NCBI notes that alternative splicing gives multiple transcript variants.
Yes. Mouse and rat both have an ortholog named Coro1a. The protein belongs to the WD repeat coronin family, which includes related members such as CORO1C. Check the datasheet of any product for its validated reactivity.
Other coronin family members and related cytoskeletal targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P31146; product specifications from Assay Genie datasheets.