CLDN5
CLDN5 (claudin 5, also known as CPETRL1, BEC1, AWAL and TMVCF) is an integral membrane protein of the claudin family. It is a component of tight junction strands and plays a major role in tight junction-specific obliteration of the intercellular space. Browse Assay Genie's current range of CLDN5 research reagents below, or read on for the biology behind the target.
CLDN5 is an integral membrane protein that localises to tight junctions and the cell membrane. According to UniProt, it plays a major role in tight junction-specific obliteration of the intercellular space. Claudins are components of tight junction strands, and these strands act as a physical barrier that prevents solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets.
The CLDN5 gene encodes a member of the claudin family, and HGNC places it in the claudins gene group. Alternative splicing of the gene results in multiple transcript variants encoding distinct isoforms. The mouse and rat orthologues are both named Cldn5, which allows the biology of this tight junction protein to be studied in common rodent models.
The gene was previously named transmembrane protein deleted in velocardiofacial syndrome, and it is also known by the aliases CPETRL1, BEC1, AWAL and TMVCF. The name reflects a disease association: mutations in this gene have been found in patients with velocardiofacial syndrome. Researchers studying paracellular barrier function, tight junction organisation or the wider claudin family often investigate CLDN5 alongside other claudins, whether as an CLDN5 antibody target, by CLDN5 ELISA kit measurement or in gene expression work.
CLDN5 contributes to tight junction strands and to obliteration of the intercellular space, making it a core subject in studies of junction structure.
Tight junction strands limit the free passage of solutes and water between cells, so CLDN5 is relevant to barrier research.
Claudins form barriers between epithelial or endothelial cell sheets, placing CLDN5 within studies of endothelial sheet integrity.
Mutations in the CLDN5 gene have been found in patients with velocardiofacial syndrome, linking it to genetic disease investigation.
CLDN5 is a claudin family membrane protein found in tight junctions. UniProt describes it as playing a major role in tight junction-specific obliteration of the intercellular space. Tight junction strands form a physical barrier that restricts solutes and water from moving through the paracellular space between cell sheets.
CLDN5 is also known as claudin 5, CPETRL1, BEC1, AWAL and TMVCF, and was formerly called transmembrane protein deleted in velocardiofacial syndrome. Alternative splicing of the gene produces multiple transcript variants that encode distinct isoforms.
Mouse and rat both have a Cldn5 orthologue. Mutations in the human gene have been found in patients with velocardiofacial syndrome. For species reactivity of any reagent, check the datasheet of any product for its validated reactivity.
Other claudin family members and tight junction proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O00501; product specifications from Assay Genie datasheets.