IFT88
IFT88 (intraflagellar transport 88, also known as Tg737, hTg737 and TTC10) is a tetratricopeptide repeat protein that positively regulates primary cilium biogenesis. It also contributes to autophagy through its role in the trafficking of ATG16L. Browse Assay Genie's current range of IFT88 research reagents below, or read on for the biology behind the target.
IFT88 is a positive regulator of primary cilium biogenesis. Its name reflects a role in intraflagellar transport, the process by which components are moved along cilia and flagella, and it belongs to the IFT-B1 complex. Beyond the cilium, UniProt annotates a second function in autophagy: IFT88 is required for trafficking of ATG16L and for expansion of the autophagic compartment. This links a ciliary protein to the cell's wider membrane-trafficking machinery.
The IFT88 gene encodes a member of the tetratricopeptide repeat (TPR) family, and the HGNC places it in the tetratricopeptide repeat domain containing group. The IFT88 protein has a broad subcellular distribution. It is found at the centrosome and centriole, at the basal body of the cilium, within cilia and flagella, and in the wider cytoplasm and cytoskeleton. This pattern fits its role in assembling and maintaining cilia from the centriole-derived basal body. Several transcript variants encoding distinct isoforms have been identified for the human gene.
The gene has carried several names. Earlier symbols and aliases include Tg737, hTg737, TTC10, D13S1056E and MGC26259, and previous names include tetratricopeptide repeat domain 10 and intraflagellar transport 88 homolog (Chlamydomonas). The mouse ortholog is Ift88. NCBI Gene notes that mutations of a similar gene in mouse can cause polycystic kidney disease, which is one reason IFT88 is widely studied in ciliopathy research.
IFT88 positively regulates primary cilium biogenesis, making it a core protein for studying how cilia are built and maintained.
As a member of the IFT-B1 complex, IFT88 is relevant to work on the organisation of intraflagellar transport machinery.
IFT88 is required for ATG16L trafficking and expansion of the autophagic compartment, connecting ciliary biology with autophagy.
Mutations of a similar gene in mouse can cause polycystic kidney disease, so IFT88 is of interest in renal ciliopathy research.
IFT88 positively regulates primary cilium biogenesis. UniProt also annotates a role in autophagy, where it is required for trafficking of ATG16L and for expansion of the autophagic compartment. The protein localises to centrioles, basal bodies, cilia and the cytoplasm.
IFT88 is also called Tg737, hTg737 and TTC10, with older identifiers D13S1056E and MGC26259. Previous names include tetratricopeptide repeat domain 10 and intraflagellar transport 88 homolog (Chlamydomonas). Several transcript variants encoding distinct isoforms have been reported.
Mouse has an ortholog, Ift88. According to NCBI Gene, mutations of a similar gene in mouse can cause polycystic kidney disease. Check the datasheet of any product for its validated reactivity.
Other intraflagellar transport proteins and ciliary targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13099; product specifications from Assay Genie datasheets.