ARID4B
ARID4B (AT-rich interactive domain-containing protein 4B) is a subunit of the SIN3A transcriptional corepressor complex that acts as a transcriptional repressor. It is also known as BCAA, BRCAA1, SAP180 and RBP1L1. Browse Assay Genie's current range of ARID4B research reagents below, or read on for the biology behind the target.
ARID4B acts as a transcriptional repressor. It is a subunit of the histone deacetylase-dependent SIN3A corepressor complex, which operates in proliferation, differentiation, apoptosis, oncogenesis and cell fate determination. UniProt notes that ARID4B may function in the assembly or enzymatic activity of the Sin3A complex, or in mediating interactions between this complex and other regulatory complexes.
The protein also has context-specific roles in chromatin regulation. At the PWS/AS imprinting centre near the SNRPN promoter, it contributes to the regulation of epigenetic modifications and may act as part of a complex with RB1 and ARID4A. In spermatogenesis, together with ARID4A, it works as a transcriptional coactivator for the androgen receptor (AR) and enhances expression of genes needed for sperm maturation. It also regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier.
In myeloid homeostasis, ARID4B regulates the histone methylation state of bone marrow cells and the expression of various genes involved in haematopoiesis, and it may function as a leukaemia suppressor. The ARID4B gene belongs to the AT-rich interaction domain containing group and was previously named retinoblastoma binding protein 1-like 1, reflecting its sequence similarity to retinoblastoma-binding protein-1. The gene product is recognised by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate splice variants encoding different isoforms have been characterised. Mouse and rat orthologues are both designated Arid4b.
ARID4B acts as a transcriptional repressor and may contribute to the assembly or activity of the Sin3A corepressor complex.
ARID4B helps regulate epigenetic modifications at the PWS/AS imprinting centre near the SNRPN promoter, possibly with RB1 and ARID4A.
With ARID4A, ARID4B coactivates the androgen receptor and regulates CLDN3, supporting sperm maturation and blood-testis barrier integrity.
ARID4B regulates histone methylation in bone marrow cells, may suppress leukaemia, and is a marker associated with many human malignancies.
ARID4B acts as a transcriptional repressor and is a subunit of the histone deacetylase-dependent SIN3A corepressor complex. It also acts as an androgen receptor coactivator in spermatogenesis, regulates CLDN3 in the testis, and influences histone methylation and gene expression in bone marrow cells.
ARID4B is also called BCAA, BRCAA1, SAP180 and RBP1L1. Earlier names include retinoblastoma binding protein 1-like 1 and AT rich interactive domain 4B (RBP1-like). Alternate splice variants encoding different isoforms have been characterised.
ARID4B may function as a leukaemia suppressor and appears to be a molecular marker associated with a broad range of human malignancies. Orthologues named Arid4b exist in mouse and rat; check the datasheet of any product for its validated reactivity.
Other AT-rich interaction domain proteins and chromatin regulators with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q4LE39; product specifications from Assay Genie datasheets.