PKNOX2
PKNOX2 (PBX/knotted 1 homeobox 2) is a nuclear homeodomain protein of the TALE class that is thought to act as a sequence-specific transcription factor. It is catalogued by UniProt as homeobox protein PKNOX2 and belongs to the TALE/MEIS homeobox family. Browse Assay Genie's current range of PKNOX2 research reagents below, or read on for the biology behind the target.
PKNOX2 is a member of the homeodomain proteins, a large group of sequence-specific transcription factors that share a highly conserved DNA-binding domain. According to the NCBI Gene summary, homeodomain proteins play fundamental roles in cell proliferation, differentiation and death. PKNOX2 is localised to the nucleus, consistent with a role in regulating gene expression.
PKNOX2 belongs to the TALE (three-amino acid loop extension) class of homeodomain proteins. This class is defined by a three-amino acid extension between alpha helices 1 and 2 within the homeodomain, a feature described for PKNOX2 by Imoto and colleagues in 2001. UniProt places the protein in the TALE/MEIS homeobox family, and HGNC lists the PKNOX2 gene within the group of TALE class homeoboxes and pseudogenes. The mouse ortholog is Pknox2.
The full name, PBX/knotted 1 homeobox 2, reflects the relationship of this gene to the PBX and knotted-type homeobox groups. No further functional annotation, tissue expression data or disease association is supplied in the UniProt and NCBI records used for this page, so researchers studying the PKNOX2 gene will often rely on the wider properties of TALE homeodomain factors as a starting framework. The PKNOX2 protein is therefore a subject for work on homeodomain-mediated transcriptional regulation and on the biology of the TALE class.
PKNOX2 is a sequence-specific DNA-binding homeodomain protein, making it relevant to studies of how conserved homeodomains regulate gene expression.
PKNOX2 carries the three-amino acid loop extension that defines TALE homeodomain proteins, supporting comparative work within this class.
Homeodomain proteins have fundamental roles in cell proliferation, differentiation and death, providing a context for investigating PKNOX2.
As a nuclear protein of the TALE/MEIS family, PKNOX2 is a candidate for work on nuclear localisation and transcriptional regulation.
PKNOX2 is a homeodomain protein, and homeodomain proteins are sequence-specific transcription factors. The NCBI Gene summary notes that this group plays fundamental roles in cell proliferation, differentiation and death. PKNOX2 is found in the nucleus, but no specific function annotation is currently provided by UniProt.
PKNOX2 belongs to the TALE (three-amino acid loop extension) class of homeodomain proteins and, in UniProt, to the TALE/MEIS homeobox family. HGNC groups the gene under TALE class homeoboxes and pseudogenes. The full name is PBX/knotted 1 homeobox 2.
A mouse ortholog, Pknox2, is recorded for the human gene. Orthology supports the use of mouse models in homeodomain research, although cross-species behaviour should be confirmed experimentally; check the datasheet of any product for its validated reactivity.
Other homeobox transcription factors and TALE class proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96KN3; product specifications from Assay Genie datasheets.