GPR75
GPR75 (G protein-coupled receptor 75, WI-31133) is a cell membrane receptor of the G protein-coupled receptor 1 family that is activated by the chemokine CCL5/RANTES. It signals through Gq-type G proteins to drive inositol trisphosphate production and calcium mobilisation. Browse Assay Genie's current range of GPR75 research reagents below, or read on for the biology behind the target.
GPR75 is a G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. It is probably coupled to heterotrimeric Gq proteins, and on activation it stimulates inositol trisphosphate production and calcium mobilisation. Like other members of the receptor family, it is a cell surface protein that activates guanine-nucleotide binding proteins when a ligand binds.
Together with CCL5/RANTES, GPR75 may play a role in neuron survival through activation of a downstream signalling pathway involving PI3 kinase, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor. These roles are described as possible, and they make GPR75 a point of interest where chemokine signalling meets neuronal and metabolic biology.
The human GPR75 gene encodes a protein that UniProt lists as the probable G protein-coupled receptor 75, localised to the cell membrane. It belongs to the G protein-coupled receptor 1 family, and HGNC places it in the group of Class A orphan GPCRs. The mouse ortholog is Gpr75. The symbol WI-31133 is recorded as an alias. Researchers studying GPR75 may use a GPR75 antibody or a GPR75 ELISA kit to examine expression and signalling in their own systems.
GPR75 is activated by CCL5/RANTES, which makes it a useful receptor for studying chemokine-driven Gq signalling, inositol trisphosphate production and calcium mobilisation.
With CCL5/RANTES, GPR75 may support neuron survival through a downstream pathway involving PI3 kinase, Akt and MAP kinases.
CCL5/RANTES may regulate insulin secretion by pancreatic islet cells through GPR75, linking the receptor to islet cell biology.
As a Class A orphan group member of the G protein-coupled receptor 1 family, GPR75 helps in the study of receptor-ligand pairing and GPCR signalling.
GPR75 is a cell surface G protein-coupled receptor activated by the chemokine CCL5/RANTES. It is probably coupled to Gq proteins and stimulates inositol trisphosphate production and calcium mobilisation. It may also contribute to neuron survival through PI3 kinase, Akt and MAP kinase signalling.
The HGNC full name is G protein-coupled receptor 75, and UniProt lists the protein as probable G protein-coupled receptor 75. The alias WI-31133 is also recorded. HGNC lists no previous names. The gene symbol and the protein name are both GPR75.
GPR75 has a mouse ortholog, Gpr75. UniProt places it in the G protein-coupled receptor 1 family, and HGNC groups it with Class A orphan GPCRs. Check the datasheet of any product for its validated reactivity.
Other G protein-coupled receptors, including orphan GPCRs related to GPR75, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O95800; product specifications from Assay Genie datasheets.