SELENBP1
SELENBP1 (selenium binding protein 1, also known as hSP56, hSBP and LPSB) is a member of the selenium-binding protein family that catalyses the oxidation of methanethiol. It is also proposed to sense reactive xenobiotics in the cytoplasm. Browse Assay Genie's current range of SELENBP1 research reagents below, or read on for the biology behind the target.
SELENBP1 is annotated in UniProt as methanethiol oxidase. It catalyses the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. The protein is also described as a selenium-binding protein that may be involved in sensing reactive xenobiotics in the cytoplasm, and it may contribute to intra-Golgi protein transport.
The SELENBP1 gene encodes a member of the selenium-binding protein family, and HGNC places it in the oxidoreductases gene group. UniProt records the SELENBP1 protein in the nucleus, the cytosol and membranes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Orthologues are present in mouse and rat, both named Selenbp1, which allows the protein to be studied in common rodent models.
Selenium is an essential nutrient with potent anticarcinogenic properties, and selenium deficiency may cause certain neurologic diseases. According to the NCBI Gene summary, these effects may be mediated by selenium-binding proteins, and decreased expression of this gene may be associated with several types of cancer. The encoded protein may also play a selenium-dependent role in ubiquitination/deubiquitination-mediated protein degradation. The aliases hSP56, hSBP and LPSB appear in the literature alongside the approved symbol.
SELENBP1 is a selenium-binding protein, so it is studied to understand how selenium, an essential nutrient, exerts its biological effects.
Decreased expression of the SELENBP1 gene may be associated with several types of cancer, making it a subject of expression studies.
SELENBP1 oxidises methanethiol, an organosulfur compound produced in substantial amounts by gut bacteria.
SELENBP1 may act in selenium-dependent ubiquitination/deubiquitination and may be involved in intra-Golgi protein transport.
SELENBP1 catalyses the oxidation of methanethiol, an organosulfur compound produced in substantial amounts by gut bacteria. It is also a selenium-binding protein that may sense reactive xenobiotics in the cytoplasm, and it may be involved in intra-Golgi protein transport.
SELENBP1 is also known as hSP56, hSBP and LPSB, and its UniProt protein name is methanethiol oxidase. Alternatively spliced transcript variants encoding multiple isoforms have been observed for the gene, so check the datasheet of any product for its validated reactivity and target region.
The NCBI Gene summary states that decreased SELENBP1 expression may be associated with several types of cancer. Selenium-binding proteins may mediate the protective effects of selenium against cancer and neurologic disease. Mouse and rat orthologues, both called Selenbp1, exist.
Other selenium-binding proteins, oxidoreductases and sulfur-metabolism enzymes with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13228; product specifications from Assay Genie datasheets.