THSD1
THSD1 (thrombospondin type-1 domain-containing protein 1, also known as TMTSP) is a positive regulator of nascent focal adhesion assembly. It is involved in modulating how endothelial cells attach to the extracellular matrix. Browse Assay Genie's current range of THSD1 research reagents below, or read on for the biology behind the target.
THSD1 acts as a positive regulator of nascent focal adhesion assembly. Focal adhesions are the sites where cells anchor to the extracellular matrix, and UniProt annotates THSD1 as involved in modulating the attachment of endothelial cells to that matrix. This makes the protein a point of interest for researchers studying cell–matrix contact and adhesion dynamics in the endothelium.
The protein encoded by the THSD1 gene contains a type 1 thrombospondin domain. According to the NCBI Gene summary, this domain is found in a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. UniProt lists several subcellular locations for the THSD1 protein: the endosome membrane, cell junction and focal adhesion, the wider membrane compartment, and a secreted form. The gene shows alternatively spliced transcript variants that encode different isoforms. The mouse ortholog is Thsd1.
The official HGNC name is thrombospondin type 1 domain containing 1, and the previous name was thrombospondin, type I, domain 1. The alias TMTSP is also in use, and you may see it in older literature. THSD1 is one of several thrombospondin type 1 domain containing genes, and THSD7A is a related target.
THSD1 is a positive regulator of nascent focal adhesion assembly, so it is relevant to studies of how adhesion sites form.
The protein is involved in modulating endothelial cell attachment to the extracellular matrix, which links it to endothelial adhesion research.
Its type 1 thrombospondin domain is found in extracellular matrix proteins, giving a structural link to matrix biology.
THSD1 is annotated at the endosome membrane as well as at focal adhesions, which suits work on adhesion-related compartments.
THSD1 is a positive regulator of nascent focal adhesion assembly. UniProt notes that it is involved in modulating endothelial cell attachment to the extracellular matrix. It is annotated at the endosome membrane and at focal adhesions, and a secreted form is also listed.
THSD1 is also known as TMTSP. Its HGNC full name is thrombospondin type 1 domain containing 1, and its previous name was thrombospondin, type I, domain 1. NCBI reports that alternatively spliced transcript variants encode different isoforms.
A mouse ortholog, Thsd1, is recorded for the human gene. The protein contains a type 1 thrombospondin domain, which NCBI notes is found in proteins of the complement pathway and in extracellular matrix proteins. Check the datasheet of any product for its validated reactivity.
Related thrombospondin type 1 domain proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9NS62; product specifications from Assay Genie datasheets.