DAZL
DAZL (deleted in azoospermia like, also known as DAZH, SPGYLA, DAZL1 and DAZLA) is an RNA-binding protein essential for gametogenesis in both males and females. It regulates the translation of key transcripts and plays a central role in spermatogenesis. Browse Assay Genie's current range of DAZL research reagents below, or read on for the biology behind the target.
DAZL is an RNA-binding protein that acts by binding to the 3'-UTR of mRNA, specifically recognising GUU triplets, and thereby regulating the translation of key transcripts. It is essential for gametogenesis in both males and females and plays a central role during spermatogenesis. The protein belongs to the RRM DAZ family.
The DAZL gene belongs to the DAZ (Deleted in AZoospermia) family, which encodes potential RNA-binding proteins expressed in prenatal and postnatal germ cells of both sexes. HGNC places it in the RNA binding motif containing group, within the DAZ RNA binding protein family. DAZL protein is found in the nucleus and cytoplasm of foetal germ cells and in the cytoplasm of developing oocytes. In the testis it is localised to the nucleus of spermatogonia, then relocates to the cytoplasm during meiosis, where it persists in spermatids and spermatozoa. Two transcript variants encoding different isoforms have been reported. The mouse ortholog is Dazl.
DAZL is autosomal. Transposition and amplification of this gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in DAZL have been linked to severe spermatogenic failure and infertility in males, which makes it a recurring subject in studies of germ cell biology and reproductive disorders.
DAZL plays a central role during spermatogenesis, and its localisation shifts from nucleus to cytoplasm as germ cells progress through meiosis.
DAZL is essential for gametogenesis in females and is found in the cytoplasm of developing oocytes.
DAZL binds GUU triplets in mRNA 3'-UTRs to regulate translation of key transcripts, making it a model for germ cell RNA control.
Mutations in DAZL have been linked to severe spermatogenic failure and infertility in males.
DAZL is an RNA-binding protein essential for gametogenesis in males and females. It binds the 3'-UTR of mRNA, recognising GUU triplets, and regulates translation of key transcripts. It plays a central role during spermatogenesis.
DAZL is the HGNC symbol for deleted in azoospermia like. Aliases and previous symbols include DAZH, SPGYLA, MGC26406, DAZL1 and DAZLA. Two transcript variants encoding different isoforms have been described for the gene.
Mutations in DAZL have been linked to severe spermatogenic failure and male infertility. During primate evolution, transposition and amplification of this autosomal gene produced the DAZ gene cluster on the Y chromosome. The mouse ortholog is Dazl; check the datasheet of any product for its validated reactivity.
Other RNA-binding proteins and germ cell markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q92904; product specifications from Assay Genie datasheets.