Wnt1
Wnt1 (Wnt family member 1, also known as INT1) is a secreted signalling protein of the Wnt family. It acts as a ligand for frizzled receptors and drives beta-catenin-dependent transcription in the canonical Wnt pathway. Browse Assay Genie's current range of Wnt1 research reagents below, or read on for the biology behind the target.
Wnt1 is a ligand for members of the frizzled family of seven transmembrane receptors. It acts in the canonical Wnt signalling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes it also serves as a ligand for the coreceptor RYK, and in doing so triggers Wnt signalling. The protein is secreted and is found in the extracellular space and extracellular matrix.
Wnt1 plays an essential role in the development of the embryonic brain and central nervous system (CNS). Studies in mouse indicate that Wnt1 functions in the induction of the mesencephalon and cerebellum. It also has a role in osteoblast function, bone development and bone homeostasis. The human Wnt1 protein is highly conserved, being 98% identical to mouse Wnt1 at the amino acid level.
The WNT gene family consists of structurally related genes that encode secreted signalling proteins, which have been implicated in oncogenesis and in developmental processes including regulation of cell fate and patterning during embryogenesis. The name INT1 and the previous name, wingless-type MMTV integration site family, member 1, reflect this history, and UniProt lists the protein as Proto-oncogene Wnt-1. The Wnt1 gene was originally considered a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature, but later studies suggested that mutations in it might not have a significant role in that disorder. It is clustered with another family member, WNT10B, in the chromosome 12q13 region.
Wnt1 engages frizzled receptors and promotes beta-catenin-dependent transcriptional activation, making it a reference ligand for studying canonical pathway activity.
Wnt1 is essential for embryonic brain and CNS development and, in mouse, for induction of the mesencephalon and cerebellum.
Wnt1 has a role in osteoblast function, bone development and bone homeostasis, linking Wnt signalling to skeletal research.
Wnt family proteins have been implicated in oncogenesis and in regulation of cell fate and patterning during embryogenesis.
Wnt1 is a secreted ligand for frizzled receptors and, in some developmental contexts, for the coreceptor RYK. It promotes beta-catenin-dependent transcriptional activation in the canonical Wnt pathway and is essential for embryonic brain and CNS development, as well as osteoblast function and bone homeostasis.
The HGNC symbol is WNT1, the full name is Wnt family member 1, and the alias is INT1. The previous name was wingless-type MMTV integration site family, member 1. UniProt lists the protein as Proto-oncogene Wnt-1 under accession P04628.
Yes. Human Wnt1 is very conserved in evolution and is 98% identical to mouse Wnt1 at the amino acid level. Mouse studies show that Wnt1 functions in induction of the mesencephalon and cerebellum. Check the datasheet of any product for its validated reactivity.
Other Wnt family ligands, including the neighbouring WNT10B gene, and related targets in Wnt signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P04628; product specifications from Assay Genie datasheets.