NDUFC2
NDUFC2 (NADH:ubiquinone oxidoreductase subunit C2, also known as B14.5b or HLC-1) is an accessory subunit of mitochondrial respiratory chain complex I. It is thought not to take part in catalysis but is required for assembly of the complex. Browse Assay Genie's current range of NDUFC2 research reagents below, or read on for the biology behind the target.
NDUFC2 is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase, also called complex I. Complex I transfers electrons from NADH to the respiratory chain, and the immediate electron acceptor for the enzyme is believed to be ubiquinone. NDUFC2 is believed not to be involved in catalysis. It is, however, required for the assembly of the complex, and NCBI Gene lists its involvement in mitochondrial respiratory chain complex I assembly. The NDUFC2 protein is located in the mitochondrial inner membrane, where it forms part of respiratory chain complex I. NCBI Gene also reports that it is predicted to enable NADH dehydrogenase (ubiquinone) activity.
The NDUFC2 gene encodes a protein of the complex I NDUFC2 subunit family. HGNC places it in the group of NADH:ubiquinone oxidoreductase supernumerary subunits, which are the non-core components of complex I. The mouse ortholog is Ndufc2, which allows the protein to be studied in murine models of mitochondrial function.
The gene has been known under several names. Aliases include B14.5b and HLC-1, and earlier HGNC names described it as NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2 (14.5kD, B14.5b). The current name, NADH:ubiquinone oxidoreductase subunit C2, reflects its place in complex I. NCBI Gene reports that NDUFC2 is implicated in nuclear type mitochondrial complex I deficiency and in stroke, which makes it relevant to research on respiratory chain assembly and mitochondrial disease.
NDUFC2 is required for assembly of complex I, so it is a relevant subunit for studying how the respiratory chain enzyme is built.
As part of complex I, NDUFC2 sits in the pathway that transfers electrons from NADH towards ubiquinone in the inner membrane.
NDUFC2 is implicated in nuclear type mitochondrial complex I deficiency, linking the subunit to inherited defects of the respiratory chain.
NCBI Gene reports an implication of NDUFC2 in stroke, giving a link between complex I components and cerebrovascular disease research.
NDUFC2 is an accessory subunit of mitochondrial complex I, the NADH dehydrogenase of the respiratory chain. It is believed not to be involved in catalysis but is required for complex assembly. Complex I transfers electrons from NADH, with ubiquinone as the believed immediate electron acceptor.
NDUFC2 is also known as B14.5b and HLC-1. Earlier HGNC names described it as NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2 (14.5kD, B14.5b). UniProt names the protein NADH dehydrogenase [ubiquinone] 1 subunit C2, and the current HGNC name is NADH:ubiquinone oxidoreductase subunit C2.
NCBI Gene reports that NDUFC2 is implicated in nuclear type mitochondrial complex I deficiency and in stroke. The mouse ortholog is Ndufc2. Check the datasheet of any product for its validated reactivity before using it in a given species.
Other complex I subunits and assembly factors that sit alongside NDUFC2 in the mitochondrial respiratory chain.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O95298; product specifications from Assay Genie datasheets.