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UGGT2
UGGT2 (UDP-glucose:glycoprotein glucosyltransferase 2, also known as HUGT2 and UGCGL2) is a glycosyltransferase of the endoplasmic reticulum. It recognises glycoproteins with minor folding defects and reglucosylates their N-glycans as part of protein quality control. Browse Assay Genie's current range of UGGT2 research reagents below, or read on for the biology behind the target.
UGGT2 acts as a folding sensor within the endoplasmic reticulum (ER). It recognises glycoproteins that carry minor folding defects and reglucosylates single N-glycans close to the misfolded region of the protein. This step provides quality control for protein folding in the ER. Reglucosylated proteins are then recognised by calreticulin, which returns them to the ER for refolding or, if folding fails, for degradation.
The UGGT2 gene encodes a member of the UDP-glucose glycoprotein glucosyltransferase group, assigned EC 2.4.1.-, and the protein belongs to the glycosyltransferase 8 family. UniProt places it in the ER lumen and in the ER-Golgi intermediate compartment. The NCBI Gene summary describes UDP-glucose:glycoprotein glucosyltransferase (UGT) as a soluble ER protein that selectively reglucosylates unfolded glycoproteins, so providing quality control for protein transport out of the ER.
The UGGT2 protein has also been recorded under the names HUGT2, UGCGL2, FLJ11485, FLJ10873, MGC150689, MGC87276 and MGC117360. Its previous HGNC name was UDP-glucose ceramide glucosyltransferase-like 2. Researchers studying glycoprotein folding, calreticulin-dependent recycling and ER proteostasis use UGGT2 as a defined component of this pathway.
UGGT2 reglucosylates N-glycans on glycoproteins with minor folding defects, making it a focus for studies of how the ER monitors folding.
Reglucosylated substrates are recognised by calreticulin and recycled for refolding or degradation, linking UGGT2 to the calreticulin cycle.
By selectively tagging unfolded glycoproteins, UGT-type enzymes provide quality control for protein transport out of the ER.
UGGT2 belongs to the glycosyltransferase 8 family and the UDP-glucose glycoprotein glucosyltransferase group, supporting comparative enzyme studies.
UGGT2 recognises glycoproteins with minor folding defects in the endoplasmic reticulum and reglucosylates single N-glycans near the misfolded region. Calreticulin then recognises these reglucosylated proteins and recycles them to the ER for refolding or degradation, which provides folding quality control.
UGGT2 is the HGNC symbol for UDP-glucose glycoprotein glucosyltransferase 2. Aliases include HUGT2, UGCGL2, FLJ11485, FLJ10873, MGC150689, MGC87276 and MGC117360. Its previous name was UDP-glucose ceramide glucosyltransferase-like 2. UniProt lists the protein as UDP-glucose:glycoprotein glucosyltransferase 2.
UGGT2 belongs to the glycosyltransferase 8 family and to the HGNC group of UDP-glucose glycoprotein glucosyltransferases. It is annotated as EC 2.4.1.- and localises to the ER lumen and ER-Golgi intermediate compartment. Check the datasheet of any product for its validated reactivity.
Other glycoprotein folding enzymes, ER chaperones and quality-control proteins studied alongside UGGT2.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9NYU1; product specifications from Assay Genie datasheets.
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