FSH
FSH, the gene symbol of which is CENPI, encodes centromere protein I (CENP-I, also known as LRPR1, Mis6 and FSHPRH1). It is a component of the centromere-associated complexes that support kinetochore assembly, mitotic progression and chromosome segregation. Browse Assay Genie's current range of FSH research reagents below, or read on for the biology behind the target.
In this page, FSH refers to centromere protein I, a structural component of the centromere rather than the pituitary hormone. The protein is part of the CENPA-CAD (nucleosome distal) complex, which is recruited to centromeres and is involved in the assembly of kinetochore proteins, mitotic progression and chromosome segregation. NCBI Gene describes it as a component of the CENPA-NAC (nucleosome-associated) complex, which is critical for accurate chromosome alignment and segregation. It may also contribute to the incorporation of newly synthesised CENPA into centromeres through its interaction with the CENPA-NAC complex.
Centromere protein I regulates the recruitment of kinetochore-associated proteins needed to generate the spindle checkpoint signal. It is required for the localisation of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. The protein is found in the nucleus and at the centromere of chromosomes, and it belongs to the CENP-I/CTF3 family. HGNC places the FSH gene in the constitutive centromere associated network gene group. Alternate splicing of the gene produces multiple transcript variants, and a pseudogene is found on chromosome 13. Mouse and rat both carry a Cenpi ortholog.
The names reflect two lines of work. The symbols LRPR1 and FSHPRH1, and the previous names 'FSH primary response (LRPR1, rat) homolog 1', come from a link to the response of gonadal tissues to follicle-stimulating hormone, a role still recorded in the UniProt annotation. Mis6 and CENP-I reflect its centromere function. NCBI Gene notes that mutations in this gene may be involved in human X-linked disorders of gonadal development and gametogenesis, which makes the FSH gene relevant to both cell division and reproductive biology.
FSH (CENP-I) belongs to the CENPA-associated complexes involved in assembling kinetochore proteins at the centromere.
The protein supports accurate chromosome alignment and segregation and helps ensure proper mitotic progression.
It regulates recruitment of kinetochore proteins, including CENPF, MAD1L1 and MAD2, that are required to generate the spindle checkpoint signal.
FSH is involved in the response of gonadal tissues to follicle-stimulating hormone, and mutations may contribute to X-linked gonadal and gametogenesis disorders.
It is a component of the CENPA-CAD and CENPA-NAC complexes at the centromere. These complexes support kinetochore assembly, mitotic progression and chromosome segregation. The protein is also required for localising CENPF, MAD1L1 and MAD2 to kinetochores, and it is involved in the response of gonadal tissues to follicle-stimulating hormone.
The HGNC symbol is CENPI. Aliases include LRPR1, CENP-I, Mis6 and FSHPRH1. Previous names, such as 'FSH primary response (LRPR1, rat) homolog 1', refer to the gonadal response to follicle-stimulating hormone. NCBI Gene also reports multiple transcript variants produced by alternate splicing.
Mouse and rat both have a Cenpi ortholog, so the gene can be studied in common model species; check the datasheet of any product for its validated reactivity. NCBI Gene reports that mutations in the human gene may be involved in X-linked disorders of gonadal development and gametogenesis.
Centromere proteins, kinetochore components and spindle checkpoint proteins that work alongside CENP-I.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q92674; product specifications from Assay Genie datasheets.