LYVE1
LYVE1 (lymphatic vessel endothelial hyaluronan receptor 1, also written LYVE-1 or XLKD1) is a type I integral membrane glycoprotein that acts as a receptor for hyaluronan. It is linked to lymphatic hyaluronan transport and to leukocyte adhesion and migration through lymphatic endothelium. Browse Assay Genie's current range of LYVE1 research reagents below, or read on for the biology behind the target.
LYVE1 is a receptor that binds both soluble and immobilised hyaluronan (HA). It binds pericellular hyaluronan matrices deposited on the surface of leukocytes, and in doing so facilitates cell adhesion and migration through lymphatic endothelium. UniProt also notes that it may act as a hyaluronan transporter, either mediating uptake for catabolism within lymphatic endothelial cells themselves, or transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
Beyond hyaluronan handling, LYVE1 is described as taking part in ligand-specific transporter trafficking between intracellular organelles, including the trans-Golgi network (TGN), and the plasma membrane. It is also reported to play a role in the autocrine regulation of cell growth mediated by growth regulators that contain a cell surface retention sequence (CRS) binding motif. The protein is a type I integral membrane glycoprotein and localises to the cell membrane. Researchers studying the LYVE1 gene in mouse work with the ortholog Lyve1.
The gene was previously known as XLKD1, from the name extracellular link domain containing 1, and the protein is often called LYVE-1 in the literature. According to the NCBI Gene summary, LYVE1 may function in lymphatic hyaluronan transport and may have a role in tumour metastasis, which makes it a frequent subject in lymphatic biology and cancer research.
LYVE1 is linked to hyaluronan transport in lymphatic endothelial cells and into afferent lymphatic vessels, making it central to studies of lymphatic function.
LYVE1 binds soluble and immobilised hyaluronan, so it is used to examine receptor interactions with hyaluronan matrices.
LYVE1 binds hyaluronan matrices on leukocytes and facilitates their adhesion and migration through lymphatic endothelium.
NCBI Gene reports that LYVE1 may have a role in tumour metastasis, supporting its investigation in cancer models.
LYVE1 is a cell membrane receptor that binds hyaluronan. It may transport hyaluronan for catabolism in lymphatic endothelial cells or into afferent lymphatic vessels, and it facilitates leukocyte adhesion and migration through lymphatic endothelium by binding pericellular hyaluronan matrices.
LYVE1 stands for lymphatic vessel endothelial hyaluronan receptor 1. It is also written LYVE-1, and the gene was previously known as XLKD1 (extracellular link domain containing 1). UniProt lists the protein as lymphatic vessel endothelial hyaluronic acid receptor 1.
Mouse has an ortholog named Lyve1. NCBI Gene states that LYVE1 may have a role in tumour metastasis, alongside its proposed function in lymphatic hyaluronan transport. Check the datasheet of any product for its validated reactivity.
Other hyaluronan receptors, lymphatic endothelial markers and lymphangiogenesis pathway proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y5Y7; product specifications from Assay Genie datasheets.