LILRA5
LILRA5 (leukocyte immunoglobulin like receptor A5, also known as ILT11, LIR9, CD85, CD85f and LILRB7) is a member of the leukocyte immunoglobulin-like receptor family. It may play a role in triggering innate immune responses. Browse Assay Genie's current range of LILRA5 research reagents below, or read on for the biology behind the target.
LILRA5 belongs to the leukocyte immunoglobulin-like receptor (LIR) family, whose members are known to have activating and inhibitory functions in leukocytes. LILRA5 is thought to contribute to the triggering of innate immune responses. Crosslinking of this receptor on the surface of monocytes has been shown to induce calcium flux and the secretion of several proinflammatory cytokines, which supports that role. UniProt notes that LILRA5 does not appear to take part in the recognition of class I MHC antigens.
UniProt lists the LILRA5 protein at both the cell membrane and in a secreted form. The gene is one of the leukocyte receptor genes that form a cluster on chromosome region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described, so researchers working with the LILRA5 gene or protein should consider which isoform is relevant to their question.
HGNC places the gene in the CD molecules group and in the activating leukocyte immunoglobulin like receptors group. Aliases include ILT11, LIR9, CD85, CD85f and LILRB7, and the earlier approved name was leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5. Related activating family members include LILRA1, LILRA2, LILRA3 and LILRA4.
LILRA5 may help trigger innate immune responses, making it a candidate for studies of how leukocytes sense and react to stimuli.
Crosslinking LILRA5 on monocytes induces calcium flux and proinflammatory cytokine secretion, offering a route to study receptor-driven monocyte activation.
Receptor engagement leads to the secretion of several proinflammatory cytokines, so LILRA5 is relevant to work on inflammatory mediator release.
As an activating member of a family with both activating and inhibitory receptors, LILRA5 informs comparative studies of leukocyte regulation.
LILRA5 may play a role in triggering innate immune responses. Crosslinking of the receptor on monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines. UniProt states it does not seem to be involved in recognition of class I MHC antigens.
LILRA5 is also known as ILT11, LIR9, CD85, CD85f and LILRB7. Its earlier name was leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5. Four alternatively spliced transcript variants encoding distinct isoforms have been described, and the protein is listed at the cell membrane and as secreted.
LILRA5 is one of the leukocyte receptor genes clustered on chromosome region 19q13.4 and belongs to the LIR family, which includes activating and inhibitory members. HGNC classifies it with the activating leukocyte immunoglobulin like receptors. Orthologue information is not given in the source data.
Other activating leukocyte immunoglobulin-like receptors from the same family with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt A6NI73; product specifications from Assay Genie datasheets.