JUND
JUND (JunD proto-oncogene, AP-1 transcription factor subunit) is a nuclear transcription factor of the Jun subfamily of bZIP proteins. It binds AP-1 sites and forms part of the AP-1 transcription factor complex, the alias under which the gene is also listed. Browse Assay Genie's current range of JUND research reagents below, or read on for the biology behind the target.
JUND is a transcription factor that binds AP-1 sites. It heterodimerises with proteins of the FOS family to form an AP-1 transcription factor complex. In doing so it enhances their DNA-binding activity to the AP-1 consensus sequence 3'-TGA[GC]TCA-5' and increases their transcriptional activity. The JUND protein is therefore best understood as a functional component of the AP-1 complex rather than as a stand-alone regulator.
The protein is a member of the JUN family and belongs to the bZIP family, Jun subfamily. HGNC places the gene in the Jun transcription factor family. UniProt records its subcellular location as the nucleus, consistent with a role in controlling gene expression. The JUND gene is intronless, and alternative translation initiation site usage results in the production of different isoforms.
The NCBI Gene summary notes that JunD has been proposed to protect cells from p53-dependent senescence and apoptosis, which makes it of interest in studies of cell survival and stress responses. Mouse and rat orthologs (both named Jund) exist, so the gene can be studied in common model systems. Researchers working on AP-1 composition often examine JUND alongside FOS family partners to separate the contributions of individual subunits.
JUND heterodimerises with FOS family proteins to form AP-1, making it a key subunit for studying how complex composition shapes DNA binding and transcription.
As a bZIP factor recognising the AP-1 consensus sequence, JUND is used to examine how AP-1 sites drive gene expression.
JunD has been proposed to protect cells from p53-dependent senescence and apoptosis, linking it to cell-fate and survival research.
The intronless JUND gene produces different isoforms through alternative translation initiation site usage, offering a model for isoform-specific function.
JUND is a transcription factor that binds AP-1 sites. It heterodimerises with FOS family proteins to form an AP-1 complex, enhancing their DNA binding to the consensus sequence 3'-TGA[GC]TCA-5' and their transcriptional activity. It has also been proposed to protect cells from p53-dependent senescence and apoptosis.
The HGNC name is JunD proto-oncogene, AP-1 transcription factor subunit, and UniProt calls the protein transcription factor JunD. AP-1 is listed as an alias. Alternative translation initiation site usage from the intronless JUND gene produces different isoforms.
Yes. Mouse and rat both have an ortholog named Jund, so the gene can be studied in standard rodent models. JUND belongs to the bZIP family, Jun subfamily; check the datasheet of any product for its validated reactivity.
Other Jun and FOS family members, AP-1 complex partners and p53 pathway targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P17535; product specifications from Assay Genie datasheets.