TNMD
TNMD (tenomodulin) is a membrane protein of the chondromodulin-1 family that is annotated as a possible angiogenesis inhibitor. It is also known as myodulin, tendin, TEM, ChM1L and BRICD4. Browse Assay Genie's current range of TNMD research reagents below, or read on for the biology behind the target.
TNMD, the tenomodulin protein, is annotated in UniProt as a molecule that may act as an angiogenesis inhibitor. The NCBI Gene summary describes the encoded protein as related to chondromodulin-I, a cartilage-specific glycoprotein that stimulates chondrocyte growth and inhibits tube formation by endothelial cells, and states that tenomodulin is also an angiogenesis inhibitor. TNMD belongs to the chondromodulin-1 family.
The human TNMD gene is located on the X chromosome and is assigned by HGNC to the BRICHOS domain containing gene group. UniProt records the protein in the membrane, the nuclear envelope and the cytoplasm. Besides tenomodulin, the protein and gene are listed under the names myodulin, tendin, TEM, ChM1L (a reference to its similarity to chondromodulin-I) and BRICD4. Orthologous genes, both named Tnmd, are found in mouse and rat, which allows the gene to be studied in those species.
In terms of disease relevance, the NCBI Gene summary reports that genetic variation in this gene is associated with risk of type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. TNMD is also a candidate gene for age-related macular degeneration, although a direct link has not yet been demonstrated. Researchers working on TNMD may therefore use the TNMD antibody, TNMD ELISA kit or TNMD protein in studies of angiogenesis and metabolic traits.
TNMD is annotated as an angiogenesis inhibitor, and its relative chondromodulin-I inhibits tube formation by endothelial cells.
TNMD is related to chondromodulin-I, a cartilage glycoprotein that stimulates chondrocyte growth, which makes it a useful comparison within the family.
Genetic variation at the TNMD gene is associated with type 2 diabetes risk and central obesity, which supports genetic and metabolic studies.
TNMD variation is linked to serum levels of systemic immune mediators in a body size-dependent manner, an association researchers can follow up.
UniProt annotates tenomodulin as a protein that may be an angiogenesis inhibitor. NCBI Gene describes it as an angiogenesis inhibitor related to chondromodulin-I, which stimulates chondrocyte growth and inhibits endothelial tube formation. It belongs to the chondromodulin-1 family.
TNMD is also called tenomodulin, myodulin, tendin, TEM, ChM1L and BRICD4. The ChM1L name reflects its relationship to chondromodulin-I, and BRICD4 reflects its place in the BRICHOS domain containing gene group.
Mouse and rat both carry a Tnmd ortholog. In humans, variation in the gene is associated with type 2 diabetes risk, central obesity and serum immune mediator levels, and it is a candidate gene for age-related macular degeneration, though a direct link is not shown. Check the datasheet of any product for its validated reactivity.
Other chondromodulin family members and angiogenesis-related targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9H2S6; product specifications from Assay Genie datasheets.