DSG2
DSG2 (desmoglein 2, also known as CDHF5) is a calcium-binding transmembrane glycoprotein of the desmosomal cadherin group. It is a component of desmosomes, the cell-cell junctions that link epithelial, myocardial and other cell types. Browse Assay Genie's current range of DSG2 research reagents below, or read on for the biology behind the target.
DSG2 is a member of the desmoglein family and of the wider cadherin cell adhesion molecule superfamily. Desmogleins are calcium-binding transmembrane glycoproteins that form part of desmosomes, the junctions that connect neighbouring epithelial, myocardial and other cell types. UniProt records localisation to the cell membrane and to desmosomes at cell junctions, with additional annotations for the cytoplasm and a secreted form.
The DSG2 gene encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. The gene sits in a cluster with other desmoglein family members on chromosome 18, alongside DSG1 and DSG3 among others. HGNC classifies the protein within the desmosomal cadherins, and CDHF5 is a recorded alias. The mouse ortholog is Dsg2.
DSG2 has clear disease relevance. Mutations in the DSG2 gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10, which makes the protein a point of interest in cardiac desmosome biology. UniProt also annotates a role in microbial infection: DSG2 is required for fibre protein-mediated infection by human adenovirus 55 and 14a, through its interaction with the viral fibre protein.
DSG2 is a calcium-binding cadherin component of desmosomes, so it is a natural subject for studies of cell-cell junction structure in epithelial and myocardial cells.
Mutations in DSG2 are associated with arrhythmogenic right ventricular dysplasia, familial, 10, making it relevant to studies of inherited heart disease.
DSG2 is required for fibre protein-mediated infection by human adenovirus 55 and 14a, through interaction with the fibre protein.
DSG2 lies in a chromosome 18 cluster with other desmogleins, supporting comparative work across the desmosomal cadherin group.
DSG2 is a calcium-binding transmembrane glycoprotein and a component of desmosomes, the cell-cell junctions of epithelial, myocardial and other cell types. UniProt also notes that it is required for fibre protein-mediated infection by human adenovirus 55 and 14a.
The HGNC name is desmoglein 2, and UniProt lists Desmoglein-2. CDHF5 is a recorded alias. The gene encodes a preproprotein that is proteolytically processed to give the mature glycoprotein, so both precursor and mature forms may be discussed.
Mutations in DSG2 have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. A mouse ortholog, Dsg2, is recorded, so rodent models can be used; check the datasheet of any product for its validated reactivity.
Other desmogleins from the same chromosome 18 cluster and desmosomal cadherin family.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q14126; product specifications from Assay Genie datasheets.