BACH1
BACH1 (BACH transcriptional regulator 1, also known as BACH-1 or BTBD24) is a nuclear transcription factor of the CNC-bZip family. It binds NF-E2 DNA sites and acts as either a repressor or an activator, depending on the context. Browse Assay Genie's current range of BACH1 research reagents below, or read on for the biology behind the target.
BACH1 is a transcriptional regulator that can act as a repressor or an activator, depending on the context. It binds to NF-E2 DNA binding sites and plays an important role in coordinating transcription activation and repression by MAFK. Together with MAF, BACH1 represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway. When the protein forms a heterodimer with MafK, it functions as a repressor of the Maf recognition element (MARE), and transcription from that element is repressed.
The BACH1 gene encodes a member of the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip); UniProt places the protein in the bZIP family, CNC subfamily. Unusually for this family, the encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains. These domains facilitate protein-protein interactions and the formation of homo- and/or hetero-oligomers. UniProt lists the protein's subcellular location as the nucleus, consistent with its role in gene regulation. Multiple alternatively spliced transcript variants have been identified for the gene.
HGNC assigns the gene to the BTB domain containing group and to the BACH transcriptional regulator family. Its previous names include BTB and CNC homology 1 and basic leucine zipper transcription factor 1, and BACH-1 and BTBD24 are recorded as aliases. The combination of a bZIP DNA-binding region with a BTB/POZ interaction domain makes BACH1 a useful subject for studies of context-dependent transcriptional control.
BACH1, together with MAF, represses genes under the control of the NFE2L2 oxidative stress pathway, making it relevant to studies of that response.
BACH1 can repress or activate transcription depending on context and coordinates activation and repression by MAFK at NF-E2 DNA binding sites.
The BACH1–MafK heterodimer represses transcription through the Maf recognition element (MARE), a model for studying repressor complexes at this site.
Its atypical BTB/POZ domains mediate protein-protein interactions and homo- or hetero-oligomer formation, which is of interest for CNC-bZip family biology.
BACH1 is a transcriptional regulator that acts as a repressor or activator depending on context. It binds NF-E2 DNA binding sites, helps coordinate transcription activation and repression by MAFK, and with MAF represses genes under the control of the NFE2L2 oxidative stress pathway.
BACH1 is the HGNC symbol for BACH transcriptional regulator 1. Aliases include BACH-1 and BTBD24, and previous names are BTB and CNC homology 1 and basic leucine zipper transcription factor 1. The UniProt entry calls it transcription regulator protein BACH1.
BACH1 belongs to the CNC-bZip family, yet it contains BTB/POZ domains, which are atypical for that family. These domains facilitate protein-protein interactions and the formation of homo- and/or hetero-oligomers. It also forms a heterodimer with MafK to repress MARE-dependent transcription.
Maf partners, oxidative stress pathway regulators and other CNC-bZip transcription factors related to BACH1.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O14867; product specifications from Assay Genie datasheets.