TMEM119
TMEM119 (transmembrane protein 119, also known as OBIF) is a membrane-associated protein that supports bone formation and normal bone mineralisation. It promotes the differentiation of myoblasts into osteoblasts and is also required for normal spermatogenesis. Browse Assay Genie's current range of TMEM119 research reagents below, or read on for the biology behind the target.
TMEM119 plays an important role in bone formation and normal bone mineralisation. It promotes the differentiation of myoblasts into osteoblasts, and is described as positively regulating osteoblast differentiation and proliferation as well as bone mineralisation. It may drive commitment of myoblasts towards the osteoblast lineage by enhancing production of BMP2 and by interacting with the BMP-RUNX2 pathway. It also up-regulates expression of ATF4, a transcription factor with a central role in osteoblast differentiation.
Beyond bone biology, the TMEM119 protein is essential for normal spermatogenesis and late testicular differentiation. UniProt lists several subcellular locations for it: the cell membrane, cytoplasm, endoplasmic reticulum membrane and secreted fractions. The NCBI Gene summary places it in the plasma membrane.
The TMEM119 gene is designated HGNC transmembrane protein 119, and OBIF is a recorded alias. A mouse ortholog, Tmem119, is also annotated. Researchers studying osteoblast differentiation, BMP signalling or testicular development use TMEM119 as a point of reference, and any TMEM119 antibody or TMEM119 ELISA kit should be matched to the experimental question and species.
TMEM119 plays an important role in bone formation and normal bone mineralisation, making it relevant to studies of skeletal development.
It promotes myoblast-to-osteoblast differentiation and up-regulates ATF4, a central transcription factor in osteoblast differentiation.
TMEM119 may enhance BMP2 production and interact with the BMP-RUNX2 pathway to drive osteoblast commitment.
The protein is essential for normal spermatogenesis and late testicular differentiation, supporting reproductive biology studies.
TMEM119 promotes bone formation and normal bone mineralisation. It drives myoblast differentiation into osteoblasts, possibly by enhancing BMP2 production and engaging the BMP-RUNX2 pathway, and it up-regulates ATF4. It is also essential for normal spermatogenesis and late testicular differentiation.
The HGNC full name is transmembrane protein 119, and the recorded alias is OBIF. UniProt uses the name Transmembrane protein 119. The gene symbol TMEM119 is the standard identifier used across HGNC, NCBI Gene and UniProt entries.
A mouse ortholog, Tmem119, is annotated for the human gene. The human protein is linked to bone mineralisation and osteoblast differentiation, and to spermatogenesis. Check the datasheet of any product for its validated reactivity.
Other transmembrane proteins in the TMEM series with research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q4V9L6; product specifications from Assay Genie datasheets.