PTGIR
PTGIR (prostaglandin I2 receptor, also known as IP or the prostacyclin receptor) is a G protein-coupled receptor that binds prostacyclin, also called prostaglandin I2 or PGI2. Its signalling is mediated by G(s) proteins, which activate adenylate cyclase. Browse Assay Genie's current range of PTGIR research reagents below, or read on for the biology behind the target.
PTGIR is the receptor for prostacyclin (prostaglandin I2, PGI2). Its activity is mediated by G(s) proteins, which in turn activate adenylate cyclase. Prostacyclin is the major product of cyclooxygenase in macrovascular endothelium, and through binding to this receptor it elicits potent vasodilation and inhibition of platelet aggregation. This places PTGIR at the centre of prostacyclin signalling in the vasculature.
The PTGIR gene encodes a protein that belongs to the G protein-coupled receptor 1 family and is localised to the cell membrane, as expected for a receptor that detects an extracellular lipid mediator. HGNC classifies it within the prostaglandin receptors gene group. Orthologous genes, named Ptgir, are recorded in both mouse and rat, so the receptor can be studied in common rodent models. Researchers working on this receptor may look for a PTGIR antibody, a PTGIR ELISA kit or recombinant PTGIR protein to examine expression and function.
The official name is prostaglandin I2 receptor. The previous HGNC name was prostaglandin I2 (prostacyclin) receptor (IP), and the symbol IP remains a widely used alias. Because the PTGIR gene product links a cyclooxygenase-derived lipid to cyclic AMP signalling through adenylate cyclase, it is a useful target for work on vascular tone and platelet biology.
Prostacyclin binding to PTGIR elicits potent vasodilation, making the receptor relevant to studies of vessel tone and endothelial signalling.
Prostacyclin acting through PTGIR inhibits platelet aggregation, so the receptor is studied in platelet regulation.
PTGIR couples to G(s) proteins and activates adenylate cyclase, offering a model for Gs-mediated receptor signalling.
Prostacyclin is the major cyclooxygenase product in macrovascular endothelium, linking PTGIR to prostaglandin receptor and cyclooxygenase studies.
PTGIR is the receptor for prostacyclin (PGI2). Its activity is mediated by G(s) proteins, which activate adenylate cyclase. Prostacyclin binding to this receptor elicits potent vasodilation and inhibition of platelet aggregation.
PTGIR is also called the prostacyclin receptor, prostaglandin I2 receptor and IP. Its previous HGNC name was prostaglandin I2 (prostacyclin) receptor (IP). HGNC places it in the prostaglandin receptors gene group.
Yes. Mouse and rat both have an ortholog named Ptgir, so the receptor can be studied in rodent systems. As with any cross-species work, check the datasheet of any product for its validated reactivity.
Other prostaglandin receptors, prostacyclin pathway enzymes and cyclooxygenase targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P43119; product specifications from Assay Genie datasheets.