ITGA5
ITGA5 (integrin subunit alpha 5, also known as CD49e or FNRA) is the alpha 5 subunit of a heterodimeric integrin that functions in cell surface adhesion and signalling. It pairs with the beta 1 subunit to form a fibronectin receptor. Browse Assay Genie's current range of ITGA5 research reagents below, or read on for the biology behind the target.
ITGA5 belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins made up of an alpha subunit and a beta subunit, and they function in cell surface adhesion and signalling. The alpha 5 subunit associates with the beta 1 subunit to form a fibronectin receptor, linking cells to the extracellular matrix. UniProt places the protein in the cell membrane and at focal adhesions, the cell junctions where integrins connect to the matrix.
The ITGA5 gene encodes a preproprotein that is proteolytically processed into light and heavy chains, which together make up the mature alpha 5 subunit. The HGNC gene group classes it among both CD molecules and integrin alpha subunits, and CD49e is the CD designation used for the protein. Researchers working with the ITGA5 gene or protein should note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.
The gene was previously named integrin, alpha 5 (fibronectin receptor, alpha polypeptide), and FNRA remains a listed alias. In disease research, this integrin may promote tumour invasion, and higher expression of the gene may be correlated with shorter survival time in lung cancer patients. UniProt also notes that, in HIV-1 infection, interaction with extracellular viral Tat protein appears to enhance angiogenesis in Kaposi's sarcoma lesions.
ITGA5 is part of an integrin that functions in cell surface adhesion and signalling, making it a focus for studies of how cells interact with fibronectin.
This integrin may promote tumour invasion, so ITGA5 is studied in relation to how cancer cells spread.
Higher expression of the gene may be correlated with shorter survival time in lung cancer patients, prompting expression studies.
In HIV-1 infection, interaction with viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
ITGA5 encodes the integrin alpha 5 subunit, which associates with the beta 1 subunit to form a fibronectin receptor. Integrins are heterodimeric membrane proteins that function in cell surface adhesion and signalling, and this one is found at the cell membrane and in focal adhesions.
ITGA5 is also called CD49e and FNRA. Its previous HGNC name was integrin, alpha 5 (fibronectin receptor, alpha polypeptide). It should not be confused with integrin alpha V, which is encoded by a distinct gene. The preproprotein is processed into light and heavy chains.
This integrin may promote tumour invasion, and higher ITGA5 expression may be correlated with shorter survival in lung cancer patients. The mouse ortholog is Itga5. Researchers working in other species should check the datasheet of any product for its validated reactivity.
Other integrin alpha subunits and related adhesion receptors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P08648; product specifications from Assay Genie datasheets.