MACC1
MACC1 (MET transcriptional regulator MACC1, also known as 7A5 or SH3BP4L) is a transcription activator for MET and a key regulator of HGF-MET signalling. It promotes cell motility, proliferation and tumour growth and metastasis. Browse Assay Genie's current range of MACC1 research reagents below, or read on for the biology behind the target.
MACC1 acts as a transcription activator for MET and is a key regulator of signalling through the hepatocyte growth factor (HGF) and its receptor, MET (also called HGFR). This pathway is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness and metastasis. In vitro, the MACC1 protein promotes cell motility, proliferation and HGF-dependent scattering. In vivo, it promotes tumour growth and metastasis.
The MACC1 gene encodes metastasis-associated in colon cancer protein 1, which is found in the cytoplasm and the nucleus. The nuclear location fits its role in activating MET transcription. HGNC places MACC1 in the ZU5 domain containing and SH3 domain containing gene groups. The approved full name is MET transcriptional regulator MACC1, and the protein is also known by the aliases 7A5 and SH3BP4L.
The name reflects how the gene was first characterised. MACC1 expression in colon cancer specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009). That link has made MACC1 a frequent subject in studies of metastatic progression. Researchers who study HGF-MET signalling, whether through MACC1 antibody or MACC1 ELISA kit based approaches, use it to follow how this regulator relates to invasive behaviour.
MACC1 expression in colon cancer specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival.
MACC1 activates MET transcription and is a key regulator of the HGF-MET pathway that controls growth and invasiveness.
MACC1 promotes cell motility and HGF-dependent scattering in vitro, making it relevant to studies of invasive behaviour.
The HGF-MET pathway regulated by MACC1 is involved in epithelial-mesenchymal transition, angiogenesis and metastasis.
MACC1 acts as a transcription activator for MET and is a key regulator of HGF-MET signalling. It promotes cell motility, proliferation and HGF-dependent scattering in vitro, and tumour growth and metastasis in vivo. It is found in the cytoplasm and nucleus.
The HGNC full name is MET transcriptional regulator MACC1. UniProt calls it metastasis-associated in colon cancer protein 1. Aliases and previous symbols are 7A5 and SH3BP4L, and the previous gene name was metastasis associated in colon cancer 1.
Yes. MACC1 expression in colon cancer specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival. It regulates HGF-MET signalling, which is involved in invasiveness and metastasis. Check the datasheet of any product for its validated reactivity.
Pathway partners of MACC1, including HGF and its receptor MET, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6ZN28; product specifications from Assay Genie datasheets.