IGFBP-7
IGFBP-7 (insulin-like growth factor-binding protein 7) is a secreted member of the IGFBP family that binds IGF1 and IGF2 with relatively low affinity. It also stimulates prostacyclin production and cell adhesion, and is known by the aliases MAC25, PSF and FSTL2. Browse Assay Genie's current range of IGFBP-7 research reagents below, or read on for the biology behind the target.
IGFBP-7 belongs to the insulin-like growth factor (IGF)-binding protein family. IGFBPs as a group bind IGFs, regulate IGF availability in body fluids and tissues, and modulate IGF binding to its receptors. IGFBP-7 differs from the classical members in that it binds IGF-I and IGF-II with relatively low affinity, placing it in a subfamily of low-affinity IGFBPs.
Beyond IGF binding, IGFBP-7 has activities of its own. It stimulates prostacyclin (PGI2) production and promotes cell adhesion, and it acts as a ligand for CD93 to play a role in angiogenesis. The protein is secreted. The IGFBP7 gene is classified by HGNC in the I-set domain containing group, and the mouse ortholog is Igfbp7.
The protein has appeared in the literature under several names, including MAC25, PSF and FSTL2, as well as insulin-like growth factor binding protein 7. Alternatively spliced transcript variants encoding different isoforms have been described for the gene, and one variant has been associated with retinal arterial macroaneurysm. Researchers studying IGF signalling, vascular biology and cell adhesion often examine IGFBP-7 alongside the other IGFBP family members.
IGFBP-7 binds IGF-I and IGF-II with low affinity, making it a useful comparator to high-affinity IGFBPs when studying IGF availability.
IGFBP-7 acts as a ligand for CD93 and plays a role in angiogenesis, linking it to vascular biology studies.
IGFBP-7 stimulates cell adhesion, so it is examined in work on how secreted factors influence cell attachment.
IGFBP-7 stimulates prostacyclin (PGI2) production, which is relevant to research on vascular mediators and endothelial responses.
IGFBP-7 is a secreted protein that binds IGF1 and IGF2 with relatively low affinity. It stimulates prostacyclin production and cell adhesion, and acts as a ligand for CD93, through which it contributes to angiogenesis.
The gene symbol is IGFBP7, and aliases include MAC25, PSF and FSTL2. Alternatively spliced transcript variants encoding different isoforms have been described, and one variant has been associated with retinal arterial macroaneurysm.
A mouse ortholog, Igfbp7, is recorded for the human gene. Whether a given reagent recognises it depends on the product, so check the datasheet of any product for its validated reactivity.
Other members of the IGFBP family, which regulate IGF availability and receptor binding, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q16270; product specifications from Assay Genie datasheets.