SH3GL1
SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2) is a member of the endophilin family of Src homology 3 domain-containing proteins, implicated in endocytosis. It is also known as SH3P8, SH3D2B, CNSA1 and EEN. Browse Assay Genie's current range of SH3GL1 research reagents below, or read on for the biology behind the target.
SH3GL1, also called endophilin-A2, is implicated in endocytosis. In a first step it mediates neck formation during ultrafast endocytosis, and at a second step it helps remove clathrin coats from the regenerated vesicles. It may also recruit other proteins to membranes with high curvature, which fits its place among the N-BAR domain containing proteins.
The SH3GL1 gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. HGNC places it in both the N-BAR domain containing and SH3 domain containing gene groups. UniProt records the protein in the cytoplasm, at the early endosome membrane and in podosomes, a type of cell projection. Alternatively spliced transcript variants encoding multiple isoforms have been observed. Pseudogenes of the gene are located on the long arm of chromosomes 11 and 17. Mouse and rat both carry an ortholog named Sh3gl1.
Beyond membrane trafficking, NCBI Gene notes that the encoded protein may play a role in the cell cycle. Overexpression of the gene may play a role in leukemogenesis, and the protein has been implicated in acute myeloid leukaemia as a fusion partner of the myeloid-lymphoid leukaemia protein. The gene has previously been named SH3-domain GRB2-like 1, and further aliases include MGC111371. Researchers studying the SH3GL1 gene or protein often work on vesicle formation, membrane curvature and leukaemia biology.
SH3GL1 mediates neck formation in ultrafast endocytosis and aids the removal of clathrin coats from regenerated vesicles.
As an N-BAR domain protein, SH3GL1 may recruit other proteins to membranes with high curvature.
SH3GL1 is a fusion partner of the myeloid-lymphoid leukaemia protein in acute myeloid leukaemia, and its overexpression may contribute to leukemogenesis.
NCBI Gene reports that SH3GL1 may play a role in the cell cycle in addition to its function in endocytosis.
SH3GL1 is implicated in endocytosis. It mediates neck formation during ultrafast endocytosis, then helps remove clathrin coats from the regenerated vesicles. It may also recruit other proteins to highly curved membranes. NCBI Gene adds a possible role in the cell cycle.
SH3GL1 is the HGNC symbol for SH3 domain containing GRB2 like 1, endophilin A2. UniProt calls the protein Endophilin-A2. Aliases and previous symbols include SH3P8, SH3D2B, CNSA1, EEN and MGC111371. Multiple isoforms arise from alternatively spliced transcript variants.
The protein has been implicated in acute myeloid leukaemia as a fusion partner of the myeloid-lymphoid leukaemia protein, and overexpression may play a role in leukemogenesis. Mouse and rat have an ortholog named Sh3gl1; check the datasheet of any product for its validated reactivity.
Other SH3 domain-containing proteins and adaptor proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q99961; product specifications from Assay Genie datasheets.