PPP1CA
PPP1CA (protein phosphatase 1 catalytic subunit alpha, also known as PP1A, PP-1A, PP1alpha or PPP1A) is one of three catalytic subunits of protein phosphatase 1. It is a serine/threonine phosphatase that dephosphorylates its targets as part of regulatory holoenzyme complexes. Browse Assay Genie's current range of PPP1CA research reagents below, or read on for the biology behind the target.
PPP1CA encodes the alpha catalytic subunit of protein phosphatase 1 (PP1), a serine/threonine-specific protein phosphatase. On its own the catalytic subunit does not act in isolation: it associates with over 200 regulatory proteins to form holoenzymes, and these partners give the complex its high specificity for the substrates it dephosphorylates. PP1 is known to be involved in the regulation of cell division, glycogen metabolism, muscle contractility, protein synthesis and HIV-1 viral transcription. UniProt also notes that the protein is necessary for alphavirus replication.
The PPP1CA gene is broadly expressed, and the protein localises to the cytoplasm and the nucleus, including the nucleoplasm and nucleolus, as well as the postsynaptic density. It belongs to the PPP phosphatase family, PP-1 subfamily, and sits in the HGNC gene group of protein phosphatase catalytic subunits alongside the other PP1 catalytic subunits, PPP1CB and PPP1CC. Three alternatively spliced transcript variants encoding different isoforms have been reported for the gene.
Earlier gene names described it as the protein phosphatase 1, catalytic subunit, alpha isoform or isozyme, and the symbol PPP1A is a previous HGNC symbol. In disease research, increased PP1 activity has been observed in the end stage of heart failure, and studies suggest PP1 is an important regulator of cardiac function. PP1 deregulation has also been implicated in diabetes and multiple types of cancer, which makes PPP1CA a frequent subject in studies of phosphorylation-dependent signalling.
PP1 is involved in regulating cell division, so PPP1CA is studied in work on how dephosphorylation controls cell cycle processes.
Increased PP1 activity is seen in end-stage heart failure, and PP1 is considered an important regulator of cardiac function.
PP1 contributes to glycogen metabolism, and its deregulation has been implicated in diabetes, making PPP1CA relevant to metabolic studies.
PP1 deregulation is implicated in multiple cancers, and PP1 is linked to HIV-1 transcription and alphavirus replication.
PPP1CA is the alpha catalytic subunit of protein phosphatase 1, a serine/threonine phosphatase. It joins with over 200 regulatory proteins to form holoenzymes that dephosphorylate specific targets, influencing cell division, glycogen metabolism, muscle contractility and protein synthesis.
PPP1CA is also called PP1A, PP-1A, PP1alpha and PPP1A. Earlier names include protein phosphatase 1, catalytic subunit, alpha isoform. Three alternatively spliced transcript variants encoding different isoforms have been found for the gene.
PP1 deregulation is implicated in diabetes and multiple cancers, and PP1 activity is increased in end-stage heart failure. Mouse and rat both have an ortholog named Ppp1ca; check the datasheet of any product for its validated reactivity.
Other PP1 catalytic and regulatory subunits, and related PPP-family phosphatases, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P62136; product specifications from Assay Genie datasheets.