SALL4
SALL4 (spalt like transcription factor 4, also known as Sal-like protein 4, ZNF797 or dJ1112F19.1) is a C2H2-type zinc finger transcription factor. It has a key role in the maintenance and self-renewal of embryonic and haematopoietic stem cells. Browse Assay Genie's current range of SALL4 research reagents below, or read on for the biology behind the target.
SALL4 is a transcription factor with a key role in the maintenance and self-renewal of embryonic and haematopoietic stem cells. This places the SALL4 protein among the regulators that help stem cells keep their undifferentiated state, which makes it a frequent subject in stem cell and developmental biology research.
The SALL4 gene encodes a zinc finger protein that belongs to the sal C2H2-type zinc-finger protein family, and HGNC classes it in the C2H2-type zinc finger gene group. UniProt records the protein in both the nucleus and the cytoplasm, consistent with its role as a transcription factor. The mouse ortholog is Sall4. Alternative splicing of the gene results in multiple transcript variants that encode different isoforms, so researchers should consider which isoform is relevant to their experiment.
The gene was previously named sal (Drosophila)-like 4, reflecting its relationship to the Drosophila spalt gene, and it has also been listed under the symbol ZNF797. NCBI Gene describes SALL4 as thought to play a role in the development of abducens motor neurons. Defects in the gene are a cause of Duane-radial ray syndrome (DRRS), which links SALL4 to human developmental disease. Related family members such as SALL2 are often studied alongside it when comparing the biology of the spalt-like proteins.
SALL4 has a key role in maintaining and self-renewing embryonic and haematopoietic stem cells, so it is widely used as a stem cell regulator.
As a C2H2-type zinc finger transcription factor, SALL4 is studied to understand how sal family proteins control gene expression.
SALL4 is thought to play a role in the development of abducens motor neurons, linking it to cranial motor neuron research.
Defects in SALL4 cause Duane-radial ray syndrome, making it relevant to studies of inherited developmental conditions.
SALL4 is a transcription factor with a key role in the maintenance and self-renewal of embryonic and haematopoietic stem cells. NCBI Gene also reports that it is thought to play a role in the development of abducens motor neurons.
SALL4 is also known as Sal-like protein 4, ZNF797 and dJ1112F19.1, and was formerly named sal-like 4 (Drosophila). Alternative splicing produces multiple transcript variants that encode different isoforms, so check which isoform is relevant to your work.
Defects in SALL4 are a cause of Duane-radial ray syndrome (DRRS). The mouse ortholog is Sall4. Check the datasheet of any product for its validated reactivity before using it with a particular species.
Other spalt-like family members and related transcription factors with research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UJQ4; product specifications from Assay Genie datasheets.