H2AC8
H2AC8 (H2A clustered histone 8, also known as H2A/a, H2A.1, H2AFA and HIST1H2AE) encodes histone H2A type 1-B/E, a core component of the nucleosome. Nucleosomes wrap and compact DNA into chromatin, which limits DNA accessibility. Browse Assay Genie's current range of H2AC8 research reagents below, or read on for the biology behind the target.
The H2AC8 protein, histone H2A type 1-B/E, is a core component of the nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries that require DNA as a template. Histones therefore play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated through a complex set of post-translational modifications of histones, often called the histone code, and through nucleosome remodelling.
Histones are basic nuclear proteins responsible for the nucleosome structure of the chromosomal fibre in eukaryotes. A nucleosome consists of approximately 146 bp of DNA wrapped around a histone octamer made up of pairs of each of the four core histones: H2A, H2B, H3 and H4. The chromatin fibre is compacted further when the linker histone H1 interacts with the DNA between nucleosomes, forming higher order chromatin structures. H2AC8 belongs to the histone H2A family and localises to the nucleus and chromosome.
The H2AC8 gene is intronless and encodes a replication-dependent histone. Its transcripts lack polyA tails and instead contain a palindromic termination element. The gene sits in the large histone gene cluster on chromosome 6p22-p21.3. HGNC places it in the H2A histones gene group. Earlier names include histone cluster 1 H2A family member e, histone 1 H2ae and H2A histone family, member A, which is why HIST1H2AE and H2AFA still appear in older literature. Researchers working with the H2AC8 gene or H2AC8 protein should be aware of these legacy symbols when searching.
As a core nucleosome component, H2AC8 helps wrap and compact DNA into chromatin, so it is relevant to studies of chromatin organisation.
Histones limit DNA accessibility to cellular machinery, placing H2AC8 within research on how chromatin state influences transcription.
Histones contribute to DNA repair and DNA replication, making H2AC8 relevant to work on genome maintenance.
DNA accessibility is regulated by histone post-translational modifications and nucleosome remodelling, both of which frame studies of histone H2A.
H2AC8 encodes histone H2A type 1-B/E, a core component of the nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility. Histones thereby contribute to transcription regulation, DNA repair, DNA replication and chromosomal stability.
H2AC8 is also called H2A/a, H2A.1, H2AFA and HIST1H2AE. Previous names include histone cluster 1 H2A family member e, histone 1 H2ae and H2A histone family, member A. The encoded protein is histone H2A type 1-B/E.
The H2AC8 gene is intronless and encodes a replication-dependent histone of the H2A family. Its transcripts lack polyA tails and contain a palindromic termination element. It lies in the large histone gene cluster on chromosome 6p22-p21.3. A mouse ortholog, H2ac8, is listed.
Other core and linker histones that form nucleosomes and higher order chromatin, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P04908; product specifications from Assay Genie datasheets.