INTS3
INTS3 (integrator complex subunit 3, also known as INT3, SOSS-A, C1orf60 and FLJ21919) is a subunit of the Integrator complex and a component of the SOSS complex. It contributes to the DNA damage response and to genome stability. Browse Assay Genie's current range of INTS3 research reagents below, or read on for the biology behind the target.
INTS3 is a component of the SOSS complex, a multiprotein assembly that acts downstream of the MRN complex to promote DNA repair and the G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences several endpoints of the cellular DNA damage response, including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Within this complex, INTS3 is required for assembly and for stabilisation of the complex at sites of DNA damage. The SOSS complex is needed for efficient homologous recombination-dependent repair of double-strand breaks and for ATM-dependent signalling pathways.
According to the NCBI Gene summary, the INTS3 protein can form a complex with the human single-strand DNA binding proteins hSSB1 and hSSB2, together with other proteins, to mediate genome stability and the DNA damage response. It is also part of a multiprotein complex that interacts with the C-terminal domain of the RNA polymerase II large subunit and helps regulate the processing of U1 and U2 small nuclear RNAs. The protein is annotated as nuclear and cytoplasmic, and it belongs to the Integrator subunit 3 family.
The INTS3 gene was previously designated chromosome 1 open reading frame 60 (C1orf60). HGNC places it in the Integrator complex gene group. The alias SOSS-A reflects its role as subunit A of the SOSS complex, and INT3 reflects its Integrator membership. The mouse ortholog is Ints3, which is useful for researchers who study DNA repair and RNA processing in model systems.
INTS3 is required for efficient homologous recombination-dependent repair of double-strand breaks through its role in the SOSS complex.
As part of complexes with hSSB1 or hSSB2, INTS3 helps mediate genome stability and the cellular DNA damage response.
The SOSS complex acts downstream of the MRN complex to promote G2/M checkpoint activation and ATM-dependent signalling.
INTS3 is part of a complex that interacts with the RNA polymerase II C-terminal domain to regulate U1 and U2 snRNA processing.
INTS3 is a component of the SOSS complex, which functions downstream of the MRN complex to promote DNA repair and the G2/M checkpoint. It is required for assembly of the complex and its stabilisation at DNA damage sites. It also belongs to a complex involved in U1 and U2 snRNA processing.
INTS3 is also called INT3, SOSS-A, C1orf60 and FLJ21919. The full name is integrator complex subunit 3, and the previous HGNC name was chromosome 1 open reading frame 60. SOSS-A refers to its role as a subunit of the SOSS complex.
A mouse ortholog, Ints3, is recorded for the human INTS3 gene. The protein belongs to the Integrator subunit 3 family. Researchers working in other species should check the datasheet of any product for its validated reactivity.
Other Integrator complex subunits that act in snRNA processing and related nuclear pathways.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q68E01; product specifications from Assay Genie datasheets.