OLFM4
OLFM4 (olfactomedin 4, also known as OlfD, GW112, GC1 and pDP4) is a secreted extracellular matrix glycoprotein of the olfactomedin family. It facilitates cell adhesion and acts as an antiapoptotic factor that promotes tumour growth. Browse Assay Genie's current range of OLFM4 research reagents below, or read on for the biology behind the target.
OLFM4 is an extracellular matrix glycoprotein that facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin. It is also described as an antiapoptotic factor that promotes tumour growth. Its effects on cell fate depend on context: in pancreatic cancer cells it may promote proliferation by favouring the transition from the S to the G2/M phase, whereas in myeloid leukaemic cell lines it inhibits cell growth and induces differentiation and apoptosis.
The OLFM4 protein may also play a role in inhibiting the phosphorylation and deactivation of EIF4EBP1. UniProt lists its subcellular location as the extracellular space, where it is secreted, and the mitochondrion. The OLFM4 gene encodes a member of the olfactomedin family and belongs to the HGNC gene group of olfactomedin domain containing genes. A mouse ortholog, Olfm4, is recognised.
The gene was originally cloned from human myeloblasts and found to be selectively expressed in inflamed colonic epithelium, which explains the alias GW112 and others such as OlfD, GC1 and pDP4 found in the literature. Its dual association with tumour growth and with myeloid differentiation makes OLFM4 a frequent subject in cancer biology, haematology and studies of epithelial inflammation. Related olfactomedin family members include OLFM1 and OLFM3.
OLFM4 may promote pancreatic cancer cell proliferation by favouring the S to G2/M transition, and is described as promoting tumour growth.
As an antiapoptotic factor, OLFM4 inhibits growth and induces differentiation and apoptosis in myeloid leukaemic cell lines.
OLFM4 is an extracellular matrix glycoprotein that facilitates cell adhesion, most probably via cell surface lectins and cadherin.
The gene was found to be selectively expressed in inflamed colonic epithelium, linking OLFM4 to studies of colonic epithelial inflammation.
OLFM4 is a secreted extracellular matrix glycoprotein that facilitates cell adhesion, most probably through cell surface lectins and cadherin. It acts as an antiapoptotic factor that promotes tumour growth, and it may play a role in inhibiting EIF4EBP1 phosphorylation and deactivation.
The HGNC name is olfactomedin 4, and UniProt uses Olfactomedin-4. Aliases and previous symbols include OlfD, GW112, GC1 and pDP4. Searching under several of these names helps when reviewing older literature on this olfactomedin family member.
OLFM4 may promote proliferation of pancreatic cancer cells, yet it inhibits growth and induces apoptosis in myeloid leukaemic cell lines. A mouse ortholog, Olfm4, exists; check the datasheet of any product for its validated reactivity.
Other olfactomedin family members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6UX06; product specifications from Assay Genie datasheets.