LDL
Research on LDL uptake by this receptor centres on SCARF1, scavenger receptor class F member 1, also known as SREC, SREC1 and KIAA0149. It is a membrane protein expressed in endothelial cells that binds and degrades acetylated low density lipoprotein (Ac-LDL). Browse Assay Genie's current range of LDL research reagents below, or read on for the biology behind the target.
SCARF1 is a scavenger receptor that mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). It regulates the uptake of chemically modified low density lipoproteins, which places it among the receptors studied in relation to lipoprotein handling by the vascular endothelium. Beyond lipid uptake, SCARF1 mediates heterophilic interactions, which suggests a function as an adhesion protein, and it plays a role in the regulation of neurite-like outgrowth.
The SCARF1 gene encodes a membrane protein that is expressed in endothelial cells. Alternative splicing of the gene results in multiple transcript variants. Expression of the gene is regulated by the transcription factors ZNF444 (also called EZF-2) and SP1. The mouse ortholog is Scarf1, which allows the receptor to be studied in rodent models of lipoprotein biology. HGNC classifies the gene within the scavenger receptors group.
The protein was originally named scavenger receptor class F, member 1, and is still widely referred to as SREC (scavenger receptor expressed by endothelial cells) in the literature, alongside the aliases SREC1 and KIAA0149. Because it regulates the uptake of modified LDL, SCARF1 may be involved in atherogenesis, and it is a useful subject for researchers interested in how endothelial cells recognise and clear altered lipoproteins. Its related family member SCARF2 shares the class F designation, making the two proteins a natural pair for comparative work. Researchers searching for an LDL-related receptor, an SCARF1 gene or an SREC protein will find these entries described under the same target.
SCARF1 regulates uptake of chemically modified low density lipoproteins and may be involved in atherogenesis, making it relevant to vascular disease models.
The receptor mediates binding and degradation of acetylated LDL, so it is used to examine how cells take up and process modified lipoproteins.
SCARF1 is expressed in endothelial cells, where it contributes to the handling of modified LDL at the vessel wall.
SCARF1 mediates heterophilic interactions suggesting an adhesion role, and it contributes to the regulation of neurite-like outgrowth.
SCARF1 is a scavenger receptor that mediates the binding and degradation of acetylated low density lipoprotein. It also mediates heterophilic interactions, suggesting an adhesion function, and plays a role in regulating neurite-like outgrowth. It is expressed in endothelial cells and may be involved in atherogenesis.
The gene is also known as SREC, SREC1 and KIAA0149, and its previous name was scavenger receptor class F, member 1. Alternative splicing produces multiple transcript variants, so literature and datasheets may describe slightly different forms of the transcript.
A mouse ortholog, Scarf1, has been identified, supporting the use of mouse models for studying the receptor. SCARF1 expression is regulated by the transcription factors ZNF444 (EZF-2) and SP1. Check the datasheet of any product for its validated reactivity.
Other class F scavenger receptors, lipoprotein receptors and transcription factors linked to SCARF1 regulation.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q14162; product specifications from Assay Genie datasheets.