IL20RA
IL20RA (interleukin 20 receptor subunit alpha, also known as ZCYTOR7 and IL-20R1) is a membrane protein of the type II cytokine receptor family. It forms heterodimeric receptor complexes that bind several interleukin-family cytokines, including IL-19, IL-20, IL-24 and IL-26. Browse Assay Genie's current range of IL20RA research reagents below, or read on for the biology behind the target.
IL20RA is one chain of a paired receptor system. Paired with IL20RB, the IL20RA/IL20RB dimer acts as a receptor for IL-19, IL-20 and IL-24. Paired instead with IL10RB, the IL20RA/IL10RB dimer acts as a receptor for IL-26. IL20RA therefore serves as a shared subunit that lets different cytokine signals converge on related receptor complexes. The interleukin 20 receptor itself is a heterodimer of the IL20RA protein and interleukin 20 receptor beta.
The IL20RA gene encodes a member of the type II cytokine receptor family and belongs to the HGNC gene group of interleukin receptors. The mature IL20RA protein is found in the membrane. According to the NCBI Gene summary, this gene and interleukin 20 receptor beta are highly expressed in skin and are upregulated in psoriasis. IL-20, the cytokine for which the receptor is named, may be involved in epidermal function. Alternative splicing of the gene results in multiple transcript variants.
The receptor has also been described as interleukin 20 receptor, alpha, and interleukin 20 receptor alpha subunit. Its aliases include ZCYTOR7 and IL-20R1. These names appear in the older literature, so it is worth searching under each of them. The mouse ortholog is Il20ra, which allows the receptor to be studied in mouse models of cytokine signalling. Researchers working on IL20RA often study it together with its ligands and partner chains, since the biology depends on which dimer forms.
IL20RA and IL20RB are highly expressed in skin, and IL-20 may be involved in epidermal function, making this receptor relevant to skin research.
Both receptor chains of the IL-20 receptor are upregulated in psoriasis, which makes IL20RA a point of interest in studies of this condition.
IL20RA pairs with IL20RB or IL10RB to form distinct receptors, so it is useful for studying how related cytokines signal through shared subunits.
The IL20RA/IL20RB dimer binds IL-19, IL-20 and IL-24, and IL20RA/IL10RB binds IL-26, supporting work on ligand and receptor pairing.
IL20RA is a receptor subunit and does not signal alone. With IL20RB it forms a receptor for IL-19, IL-20 and IL-24. With IL10RB it forms a receptor for IL-26. It belongs to the type II cytokine receptor family.
IL20RA is also called ZCYTOR7 and IL-20R1. Earlier names include interleukin 20 receptor, alpha, and interleukin 20 receptor alpha subunit. NCBI notes that alternative splicing produces multiple transcript variants. Searching under every alias helps when reviewing older papers.
Yes, the mouse ortholog is Il20ra. NCBI reports that IL20RA and IL20RB are highly expressed in skin and upregulated in psoriasis. Check the datasheet of any product for its validated reactivity.
Ligands of the IL20RA receptor complexes and other interleukin family cytokines with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UHF4; product specifications from Assay Genie datasheets.