TXNDC17
TXNDC17 (thioredoxin domain containing 17) is a cytoplasmic disulfide reductase of the thioredoxin family that takes part in redox reactions and modulates TNF signalling. It is also known as TRP14, TXNL5 and MGC14353. Browse Assay Genie's current range of TXNDC17 research reagents below, or read on for the biology behind the target.
TXNDC17 is a disulfide reductase. It may take part in a range of redox reactions through reversible oxidation of its active-centre dithiol to a disulfide, and it can catalyse dithiol-disulfide exchange reactions. NCBI Gene annotates the protein as enabling protein-disulfide reductase [NAD(P)H] activity. TXNDC17 also has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide.
Beyond its redox chemistry, TXNDC17 modulates TNF signalling and NF-kappa-B activation, and the gene is annotated as involved in the tumour necrosis factor-mediated signalling pathway. The protein is located in the cytosol. The TXNDC17 gene belongs to the HGNC gene group of thioredoxin domain containing proteins, and the protein belongs to the thioredoxin family. A mouse ortholog, Txndc17, is recorded.
The gene was previously named thioredoxin-like 5, and the symbols TXNL5, TRP14 and MGC14353 are still found in the literature and in databases. Researchers studying TXNDC17 often work on thioredoxin-system redox control, hydrogen peroxide handling and the regulation of inflammatory signalling through TNF and NF-kappa-B, so the TXNDC17 protein is of interest wherever these pathways meet.
TXNDC17 may participate in redox reactions through dithiol-disulfide exchange, making it a subject for studies of cellular thiol-based regulation.
TXNDC17 modulates TNF signalling, so it is relevant to work on how redox enzymes shape cytokine responses.
The protein modulates NF-kappa-B activation, linking thioredoxin-family activity to inflammatory transcriptional control.
With peroxidase activity, TXNDC17 may help eliminate cellular hydrogen peroxide, which is relevant to oxidative stress studies.
TXNDC17 is a disulfide reductase that may take part in redox reactions and catalyse dithiol-disulfide exchange. It also has peroxidase activity, may help eliminate cellular hydrogen peroxide, and modulates TNF signalling and NF-kappa-B activation.
TXNDC17 is the HGNC symbol for thioredoxin domain containing 17. Aliases and previous symbols include TRP14, TXNL5 and MGC14353, and the previous gene name was thioredoxin-like 5. Check the datasheet of any product for its validated reactivity.
A mouse ortholog, Txndc17, is recorded for the human gene. The protein belongs to the thioredoxin family, which is widespread. No rat ortholog is given in the data used here. Check the datasheet of any product for its validated reactivity.
Other thioredoxin domain-containing proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BRA2; product specifications from Assay Genie datasheets.