A33 antigen, also known as glycoprotein A33, is a single-pass type I membrane protein that is expressed in the normal gastrointestinal epithelium and in 95% of colon cancers. GPA33 contains one C2-like (immunoglobulin-like) domain and one V-type (immunoglobulin-like) domain. The open reading frame encodes a 319-amino acid polypeptide with a putative secretory signal sequence and three possible glycosylation sites. The predicted mature protein has a 213-amino acid extracellular domain, a single transmembrane domain, and a 62-amino acid intracellular tail. Intracellular traffic and recycling to the cell surface appear to be essential for GPA33 function, with their influence on surface density surpassing translational control. GPA33 has become a promising target of immunologic therapy strategies, but its biologic function and potential role in tumorigenesis are unknown. The protein EpCAM and the mRNA gene GA33 are unique and sensitive indicators of Barrett's metaplasia (BM). It may also be involved in cell-cell contact recognition and signalling. Human TXNDC17/TRP14/TXNL5 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human TXNDC17/TRP14/TXNL5 Recombinant Protein (RPES2222)
Product Code:
RPES2222
Size:
20µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
TRP14,TXNL5
Accession:
Q9BRA2
Sequence:
Met 1-Asp 123
Fusion tag:
Endotoxin:
Please contact us for more information.
Protein Construction:
A DNA sequence encoding the mature form of human TXNDC17 (Q9BRA2) (Met 1-Asp 123) was expressed and purified, with an initial Met.
Purity:
> 97 % as determined by reducing SDS-PAGE.
Mol Mass:
13.9 kDa
AP Mol Mass:
13.9 kDa
Formulation:
Lyophilized from sterile PBS, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
