ERRFI1
ERRFI1 (ERBB receptor feedback inhibitor 1) is a negative regulator of EGFR family signalling, also known as MIG-6, GENE-33 and RALT. It restrains receptor activity in skin, uterus and lung, and belongs to the MIG6 family. Browse Assay Genie's current range of ERRFI1 research reagents below, or read on for the biology behind the target.
ERRFI1 acts as a feedback brake on receptor tyrosine kinase signalling. It is a negative regulator of EGFR signalling in skin morphogenesis and also restrains several other EGFR family members, including ERBB2, ERBB3 and ERBB4. The protein inhibits EGFR catalytic activity by interfering with its dimerisation, and it inhibits autophosphorylation of EGFR, ERBB2 and ERBB4.
Beyond receptor control, ERRFI1 has defined physiological roles. It is important for normal keratinocyte proliferation and differentiation, and for normal prenatal and perinatal lung development. In the uterus it helps modulate the response to steroid hormones: it is required for a normal response to progesterone and for fertility, and it mediates epithelial oestrogen responses by regulating ESR1 levels and activation. It is also important for regulating endometrium cell proliferation.
The ERRFI1 gene encodes a protein found in the cytoplasm, at the cell membrane and in the nucleus. According to the NCBI Gene summary, its expression is upregulated with cell growth. The protein shares significant homology with the product of rat gene-33, which is induced during cell stress and mediates cell signalling, which explains the aliases GENE-33 and MIG-6. RALT is a further alias. Mouse and rat orthologs are both named Errfi1, so the gene can be studied in common rodent models. Researchers working on EGFR pathway control often look at ERRFI1 protein levels alongside receptor phosphorylation.
ERRFI1 inhibits EGFR, ERBB2 and ERBB4 autophosphorylation and interferes with EGFR dimerisation, making it a key subject for studying receptor feedback control.
ERRFI1 negatively regulates EGFR signalling in skin morphogenesis and is important for normal keratinocyte proliferation and differentiation.
ERRFI1 is required for the normal progesterone response and fertility, and regulates ESR1 levels and activation in uterine epithelium.
ERRFI1 is important for normal prenatal and perinatal lung development, linking growth factor restraint to organ formation.
ERRFI1 is a negative regulator of EGFR family signalling. It inhibits EGFR catalytic activity by interfering with dimerisation and blocks autophosphorylation of EGFR, ERBB2 and ERBB4. It also supports keratinocyte proliferation and differentiation, uterine hormone responses and lung development.
ERRFI1 is also called MIG-6, GENE-33 and RALT. The full name is ERBB receptor feedback inhibitor 1. The GENE-33 name reflects homology with rat gene-33, which is induced during cell stress and mediates cell signalling. The protein belongs to the MIG6 family.
Yes. Mouse and rat both carry an ortholog named Errfi1, which allows the gene to be studied in rodent models. Check the datasheet of any product for its validated reactivity before use in a particular species.
EGFR family receptors and steroid hormone signalling partners connected to ERRFI1 biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UJM3; product specifications from Assay Genie datasheets.