NRDC
NRDC (nardilysin convertase), also known as nardilysin, NRD1, hNRD1 and hNRD2, is a zinc-dependent endopeptidase of the peptidase M16 family. It cleaves peptide substrates at the N-terminus of arginine residues in dibasic pairs and regulates neuregulin processing. Browse Assay Genie's current range of NRDC research reagents below, or read on for the biology behind the target.
NRDC is a zinc-dependent endopeptidase that cleaves peptide substrates on the N-terminal side of arginine residues within dibasic pairs. Beyond this catalytic activity, it acts as a critical activator of BACE1- and ADAM17-mediated shedding of the pro-neuregulin ectodomain. Through this role it is involved in the positive regulation of axonal maturation and myelination. NRDC is also required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH). According to NCBI Gene, the protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation.
The human NRDC gene encodes a member of the peptidase M16 family, and the enzyme carries the EC number 3.4.24.61. UniProt records its subcellular locations as the mitochondrion and dendrites, a cell projection. Multiple transcript variants encoding different isoforms have been reported for the gene. Mouse and rat both have an orthologous Nrdc gene, so the protein can be studied in common rodent models, although researchers should check the datasheet of any product for its validated reactivity.
The HGNC-approved name is nardilysin convertase, and the previous name was nardilysin (N-arginine dibasic convertase). Earlier symbols include NRD1, hNRD1 and hNRD2. HGNC places NRDC in the M16 metallopeptidases gene group and also in the group of microRNA protein coding host genes. Researchers looking for an NRDC antibody, NRDC ELISA kit or recombinant NRDC protein will often find the protein listed under the older name nardilysin.
NRDC activates BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, making it relevant to studies of ectodomain shedding and neuregulin signalling.
NRDC is involved in the positive regulation of axonal maturation and myelination, which makes it a target of interest in neural development research.
NRDC is required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH), linking the protein to mitochondrial enzyme activity.
NRDC interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation.
NRDC is a zinc-dependent endopeptidase that cleaves peptides at the N-terminus of arginine residues in dibasic pairs. It activates BACE1- and ADAM17-mediated pro-neuregulin shedding, supports axonal maturation and myelination, and is required for proper OGDH function.
NRDC is the HGNC symbol for nardilysin convertase. The protein is also called nardilysin or N-arginine dibasic convertase, and earlier symbols include NRD1, hNRD1 and hNRD2. NCBI Gene notes that multiple transcript variants encode different isoforms.
Yes. Mouse and rat each have an orthologous gene named Nrdc, so rodent models can be used to study the protein. NRDC belongs to the peptidase M16 family. Check the datasheet of any product for its validated reactivity.
Neuregulin-processing proteases, growth factor partners and mitochondrial enzymes linked to NRDC function.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O43847; product specifications from Assay Genie datasheets.