FOXO4
FOXO4 (forkhead box O4, also known as AFX1 and MLLT7) is a member of the O class of winged helix/forkhead transcription factors. It acts in the insulin signalling pathway and in the negative regulation of the cell cycle. Browse Assay Genie's current range of FOXO4 research reagents below, or read on for the biology behind the target.
FOXO4 is a transcription factor involved in regulating the insulin signalling pathway. It binds insulin-response elements (IREs) and can activate transcription of IGFBP1. It also down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. In addition, it contributes to the negative regulation of the cell cycle.
In embryonic stem cells (ESCs), the FOXO4 protein activates expression of PSMD11. This leads to enhanced assembly of the 26S proteasome and higher proteasome activity. The protein is found in both the cytoplasm and the nucleus. The FOXO4 gene encodes a member of the O class of winged helix/forkhead transcription factors, which belong to the HGNC group of forkhead boxes. Proteins of this class are regulated by factors involved in growth and differentiation, which indicates a role in these processes. Multiple transcript variants encoding different isoforms have been reported. The mouse ortholog is Foxo4.
The gene was first named for a disease-associated rearrangement. A translocation between chromosome X, where FOXO4 lies, and the homolog of the Drosophila trithorax gene on chromosome 11 is associated with leukaemia. This explains the alias MLLT7 (myeloid/lymphoid or mixed-lineage leukaemia translocated to 7) and the older symbol AFX1. FOXO4 is studied alongside other FOXO family members such as FOXO1, FOXO3 and FOXO6.
FOXO4 regulates the insulin signalling pathway and binds insulin-response elements, including activation of IGFBP1 transcription.
FOXO4 down-regulates HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes.
FOXO4 is involved in negative regulation of the cell cycle and is regulated by growth and differentiation factors.
In embryonic stem cells, FOXO4 activates PSMD11 expression, enhancing 26S proteasome assembly and proteasome activity.
FOXO4 is a transcription factor in the insulin signalling pathway. It binds insulin-response elements, can activate IGFBP1 transcription, down-regulates HIF1A, and contributes to negative regulation of the cell cycle. In embryonic stem cells it activates PSMD11, increasing proteasome activity.
FOXO4 is also known as AFX1 and MLLT7. The previous names refer to myeloid/lymphoid or mixed-lineage leukaemia (trithorax homolog, Drosophila) translocated to 7. The gene produces multiple transcript variants that encode different isoforms.
A translocation between the X chromosome, at the FOXO4 locus, and the trithorax homolog gene on chromosome 11 is associated with leukaemia. FOXO4 has a mouse ortholog, Foxo4; check the datasheet of any product for its validated reactivity.
Other FOXO family forkhead transcription factors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P98177; product specifications from Assay Genie datasheets.