PLS1
PLS1 (plastin 1) is an actin-bundling protein of the plastin family, previously named plastin 1 (I isoform). It is required for stereocilia formation in the inner ear and is expressed at high levels in the small intestine. Browse Assay Genie's current range of PLS1 research reagents below, or read on for the biology behind the target.
PLS1 is an actin-bundling protein. In the inner ear it is required for stereocilia formation, where it mediates liquid packing of actin filaments. This packing is necessary for stereocilia to grow to their proper dimensions. The PLS1 protein is found in the cytoplasm and in the stereocilium, a cell projection.
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms, L and T, have been identified. The protein encoded by the PLS1 gene is a third, distinct plastin isoform. Unlike the other two, it is specifically expressed at high levels in the small intestine. HGNC places it in the plastin family and in the EF-hand domain containing group.
The PLS1 gene produces alternatively spliced transcript variants that differ in the 5' UTR but encode the same protein. A pseudogene of the gene is found on chromosome 11. The mouse ortholog is Pls1. The earlier name for the gene product was plastin 1 (I isoform), which reflects its position as the third human plastin alongside the L and T forms. Researchers studying actin organisation, cytoskeletal bundling, hearing biology or intestinal cell structure may use PLS1 as a target of interest.
PLS1 is required for stereocilia formation in the inner ear, making it relevant to studies of how these actin-based structures develop.
As an actin-bundling protein, PLS1 mediates liquid packing of actin filaments, a mechanism studied in cytoskeletal architecture.
PLS1 is specifically expressed at high levels in the small intestine, which suits work on tissue-specific actin regulation there.
PLS1 is the third human plastin isoform alongside the ubiquitous L and T forms, supporting comparative work across the family.
PLS1 is an actin-bundling protein. In the inner ear it is required for stereocilia formation, and it mediates liquid packing of actin filaments. This packing is necessary for stereocilia to grow to their proper dimensions.
HGNC lists plastin 1 as the gene name, with the previous name plastin 1 (I isoform). The gene has alternatively spliced transcript variants that differ in the 5' UTR but all encode the same protein.
Plastins are conserved actin-binding proteins across eukaryotes. Humans have two ubiquitous isoforms, L and T, and PLS1 is a third, distinct isoform expressed at high levels in the small intestine. Mouse has the ortholog Pls1; check the datasheet of any product for its validated reactivity.
Other plastin family members and similarly named targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q14651; product specifications from Assay Genie datasheets.