LRIG3
LRIG3 (leucine rich repeats and immunoglobulin like domains 3) is a membrane protein that may contribute to craniofacial and inner ear development. It is also known by the aliases KIAA3016 and FLJ90440, and belongs to the I-set domain containing gene group. Browse Assay Genie's current range of LRIG3 research reagents below, or read on for the biology behind the target.
LRIG3 may play a role in craniofacial and inner ear morphogenesis during embryonic development. According to UniProt, it may act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1. These functional assignments are described as probable rather than established, and the detailed molecular mechanism remains to be defined.
The LRIG3 protein is localised to the cell membrane and to the membrane of cytoplasmic vesicles. Its name reflects its domain architecture, with leucine-rich repeats and immunoglobulin-like domains. HGNC places the LRIG3 gene in the I-set domain containing group. The mouse ortholog is Lrig3, which is relevant for researchers studying developmental questions in model systems.
NCBI Gene, drawing on Alliance of Genome Resources predictions, indicates that LRIG3 is predicted to enable signalling receptor activity and to be involved in sensory perception of sound. It is also predicted to act upstream of or within otolith morphogenesis. Together with the UniProt annotation, this points to a role in the development of the inner ear and the sensory structures that support hearing and balance. Researchers working with LRIG3 may also encounter the older designations KIAA3016 and FLJ90440 in the literature and in sequence databases.
LRIG3 may act in the otic vesicle epithelium to control formation of the lateral semicircular canal.
LRIG3 may play a role in craniofacial development during the embryonic period.
LRIG3 is predicted to be involved in sensory perception of sound and in otolith morphogenesis.
LRIG3 is predicted to enable signalling receptor activity at the cell membrane and on cytoplasmic vesicle membranes.
LRIG3 may play a role in craniofacial and inner ear morphogenesis during embryonic development. It may act within the otic vesicle epithelium to control lateral semicircular canal formation, possibly by restricting NTN1 expression. These roles are described as possible, so interpret them with care.
The HGNC full name is leucine rich repeats and immunoglobulin like domains 3, and UniProt lists it as leucine-rich repeats and immunoglobulin-like domains protein 3. Aliases include KIAA3016 and FLJ90440. HGNC classifies the gene within the I-set domain containing group.
Yes, the mouse ortholog is Lrig3. The UniProt annotation on semicircular canal formation and the NCBI predictions on otolith morphogenesis both concern inner ear development, which makes model organisms useful for study. Check the datasheet of any product for its validated reactivity.
Other I-set domain proteins, developmental regulators and inner ear research targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6UXM1; product specifications from Assay Genie datasheets.