TNFAIP2
TNFAIP2 (TNF alpha induced protein 2, also known as B94 and EXOC3L3) is a member of the SEC6 family whose expression is induced by tumour necrosis factor alpha. It may act as a mediator of inflammation and angiogenesis. Browse Assay Genie's current range of TNFAIP2 research reagents below, or read on for the biology behind the target.
TNFAIP2 is a protein that may play a role as a mediator of inflammation and angiogenesis. UniProt describes this function in tentative terms, and the detailed molecular mechanism is not defined in the sources used here. The protein belongs to the SEC6 family, and the alias EXOC3L3 reflects that relationship. Subcellular location is not annotated in UniProt.
The TNFAIP2 gene was identified because its expression can be induced by tumour necrosis factor alpha (TNF) in umbilical vein endothelial cells. This links the gene to the endothelial response to a major pro-inflammatory cytokine, and it fits the proposed role in inflammation and in angiogenesis. Researchers looking at TNF-driven transcriptional responses therefore often consider the TNFAIP2 gene as one readout of that signalling.
A second line of evidence comes from cancer biology. Expression of TNFAIP2 was shown to be induced by retinoic acid in a cell line expressing an oncogenic version of the retinoic acid receptor alpha fusion protein. This suggested that the gene may be a retinoic acid target gene in acute promyelocytic leukaemia.
The gene is also known by the alias B94, and its previous HGNC name was tumour necrosis factor, alpha-induced protein 2. A mouse ortholog, Tnfaip2, is recorded. Together, the TNF-inducible and retinoic acid-inducible expression patterns make TNFAIP2 a useful subject for studies of inflammatory gene regulation, endothelial biology and leukaemia-associated transcription. Studies of the TNFAIP2 protein can help clarify how it contributes to these processes.
TNFAIP2 may mediate inflammation, and its expression is induced by TNF, making it relevant to studies of cytokine-driven responses.
UniProt proposes a role for TNFAIP2 in angiogenesis, supporting its study in endothelial and vascular biology.
The gene was identified through TNF induction in umbilical vein endothelial cells, a classic model for endothelial activation.
TNFAIP2 may be a retinoic acid target gene in acute promyelocytic leukaemia, linking it to oncogenic RARA fusion signalling.
According to UniProt, TNFAIP2 may play a role as a mediator of inflammation and angiogenesis. The wording is cautious, so the precise mechanism is not established in the sources used here. The gene is inducible by TNF in endothelial cells, which fits an inflammatory role.
TNFAIP2 is also called B94 and EXOC3L3. Its full HGNC name is TNF alpha induced protein 2, and a previous name was tumour necrosis factor, alpha-induced protein 2. The EXOC3L3 alias reflects its membership of the SEC6 family.
TNFAIP2 expression is induced by retinoic acid in cells expressing an oncogenic RARA fusion protein, suggesting it may be a retinoic acid target gene in acute promyelocytic leukaemia. A mouse ortholog, Tnfaip2, exists. Check the datasheet of any product for its validated reactivity.
Other TNF alpha-induced proteins that are relevant to inflammation research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q03169; product specifications from Assay Genie datasheets.