GAB1
GAB1 (GRB2 associated binding protein 1, also known as DFNB26) is an adapter protein that acts in intracellular signalling cascades triggered by activated receptor-type kinases. It belongs to the GAB family and is involved in MET/HGF signalling. Browse Assay Genie's current range of GAB1 research reagents below, or read on for the biology behind the target.
GAB1 is an adapter protein that plays a role in intracellular signalling cascades triggered by activated receptor-type kinases. It has a role in FGFR1 signalling and is probably involved in signalling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). It is also involved in the MET/HGF signalling pathway. As an adapter, it carries no enzymatic activity of its own; it relays signals from activated receptors to downstream components of the cascade.
The GAB1 gene encodes a member of the IRS1-like multisubstrate docking protein family, and UniProt places the protein in the GAB family. According to the NCBI Gene summary, it is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been described for this gene. The mouse ortholog is Gab1, which is relevant when planning cross-species work with a GAB1 antibody, GAB1 ELISA kit or recombinant GAB1 protein.
HGNC classifies the GAB1 gene within the pleckstrin homology domain containing group and among the microRNA protein coding host genes. The symbol DFNB26 is a previous symbol, and the previous gene name was deafness, autosomal recessive 26. Researchers studying receptor tyrosine kinase signalling, growth factor responses and tubulogenesis often use GAB1 as a readout for pathway activation, alongside its relative GAB2.
GAB1 is an adapter acting downstream of activated receptor-type kinases, making it relevant to studies of intracellular signalling cascades.
GAB1 is involved in the MET/HGF signalling pathway, a context in which it is studied as a signalling mediator.
GAB1 plays a role in FGFR1 signalling and is probably involved in EGFR and insulin receptor signalling.
GAB1 is described as an important mediator of branching tubulogenesis and has a central role in growth response, transformation and apoptosis.
GAB1 is an adapter protein that functions in intracellular signalling cascades triggered by activated receptor-type kinases. It plays a role in FGFR1 signalling, is probably involved in EGFR and insulin receptor signalling, and takes part in the MET/HGF pathway. It also mediates branching tubulogenesis and growth responses.
GAB1 stands for GRB2 associated binding protein 1. DFNB26 is a previous symbol, from the earlier name deafness, autosomal recessive 26. NCBI Gene reports two transcript variants that encode different isoforms. Check the datasheet of any product for its validated reactivity and isoform coverage.
GAB1 has a mouse ortholog, Gab1. The protein belongs to the GAB family and is described as a member of the IRS1-like multisubstrate docking protein family. GAB2 is a related family member. Check the datasheet of any product for its validated reactivity.
GAB2, another member of the GAB adapter family, with related signalling targets.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13480; product specifications from Assay Genie datasheets.