H2AC25
H2AC25 (H2A clustered histone 25, also known as HIST3H2A, H2AW and MGC3165) encodes histone H2A type 3, a core component of the nucleosome. It helps wrap and compact DNA into chromatin, limiting access of cellular machinery to the DNA template. Browse Assay Genie's current range of H2AC25 research reagents below, or read on for the biology behind the target.
H2AC25 is a core component of the nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries that use DNA as a template. Histones therefore play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Access to DNA is regulated through a complex set of post-translational modifications of histones, often called the histone code, together with nucleosome remodelling.
The H2AC25 protein, histone H2A type 3, belongs to the histone H2A family and is found in the nucleus, associated with chromosomes. Histones are basic nuclear proteins responsible for the nucleosome structure of the chromosomal fibre in eukaryotes. A nucleosome consists of approximately 146 bp of DNA wrapped around a histone octamer made up of pairs of each of the four core histones: H2A, H2B, H3 and H4. The chromatin fibre is compacted further when the linker histone H1 interacts with the DNA between nucleosomes, forming higher order chromatin structures.
The H2AC25 gene is intronless and encodes a replication-dependent histone. Its transcripts contain a palindromic termination element. HGNC classifies it in the H2A histones gene group. The symbol has changed over time: earlier names include HIST3H2A, histone cluster 3 H2A and H2A.W histone, reflecting its former place in histone cluster 3. Mouse and rat orthologs are both designated H2ac25.
H2AC25 is a core nucleosome component, so it is relevant to studies of how DNA is wrapped and compacted into chromatin.
Histones limit DNA accessibility and contribute to transcription regulation, making H2A proteins relevant to studies of gene expression control.
Histones play a central role in DNA repair and DNA replication, and H2AC25 is a replication-dependent histone.
DNA accessibility is regulated by histone post-translational modifications and nucleosome remodelling, central topics in epigenetics research.
H2AC25 encodes histone H2A type 3, a core component of the nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility. Histones thereby contribute to transcription regulation, DNA repair, DNA replication and chromosomal stability.
H2AC25 (H2A clustered histone 25) was previously known as HIST3H2A, with aliases MGC3165 and H2AW. Earlier gene names include histone cluster 3 H2A and H2A.W histone. The protein is called histone H2A type 3 in UniProt.
Yes. Mouse and rat orthologs are both named H2ac25. The protein belongs to the histone H2A family, and histones are the basic nuclear proteins that form nucleosomes in eukaryotes. Check the datasheet of any product for its validated reactivity.
Other histone H2A family members and core histones that make up the nucleosome octamer.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q7L7L0; product specifications from Assay Genie datasheets.