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UBL4B
UBL4B (ubiquitin like 4B, also known as FLJ25690) is a human ubiquitin-like protein encoded on chromosome 1. It is predicted to be located in the cytoplasm and has been linked to the regulation of protein targeting to mitochondria. Browse Assay Genie's current range of UBL4B research reagents below, or read on for the biology behind the target.
UBL4B is a ubiquitin-like protein. According to the NCBI Gene summary, which is provided by the Alliance of Genome Resources, the gene is involved in what is now an obsolete Gene Ontology process, positive regulation of protein targeting to mitochondrion. The same summary predicts that the protein is located in the cytoplasm, which agrees with the UniProt subcellular location annotation. No curated UniProt function annotation is currently available for this protein, so its precise molecular mechanism remains to be defined.
The UBL4B gene is located at 1p13.3, and the encoded protein is catalogued in UniProt under accession Q8N7F7. The identifiers used by HGNC and NCBI Gene are HGNC:32309 and 164153. The mouse ortholog is Ubl4b, which allows the gene to be studied in rodent models. Because the sources supply no tissue expression data, expression patterns should be established experimentally.
The approved HGNC name is ubiquitin like 4B, and the previous name was ubiquitin-like 4B. The earlier symbol FLJ25690 may still appear in older literature and databases. UBL4A is a related ubiquitin-like 4 family member that researchers often consider alongside UBL4B when they compare the two proteins. Any UBL4B antibody, UBL4B ELISA kit or UBL4B protein reagent should be chosen with this naming history in mind, so that the correct gene product is being measured.
UBL4B has been annotated as involved in positive regulation of protein targeting to mitochondrion, making it a candidate for studies of this process.
As a ubiquitin-like protein, UBL4B offers a subject for comparison with other family members, including UBL4A.
UBL4B is predicted to be cytoplasmic, so it suits subcellular localisation and fractionation studies that test this prediction.
With limited curated functional annotation, the UBL4B gene is an open subject for work on its roles and mechanisms.
The NCBI Gene summary says UBL4B is involved in positive regulation of protein targeting to mitochondrion, an obsolete Gene Ontology term, and is predicted to be located in the cytoplasm. No curated UniProt function annotation is available, so its detailed molecular role remains to be established.
UBL4B stands for ubiquitin like 4B. UniProt lists it as ubiquitin-like protein 4B, HGNC records the previous name ubiquitin-like 4B, and FLJ25690 is an earlier alias. Searching under all of these names helps when reviewing older literature and database entries.
A mouse ortholog, Ubl4b, is recorded for the human gene. No rat ortholog is listed in the data used for this page. Researchers working in other species should check the datasheet of any product for its validated reactivity.
A related ubiquitin-like 4 family member with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8N7F7; product specifications from Assay Genie datasheets.
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