PTGER2
PTGER2 (prostaglandin E receptor 2, also known as EP2) is a cell-surface receptor for prostaglandin E2 (PGE2). It signals through G(s) proteins to raise intracellular cAMP, and the symbol COX-2 also appears among its listed aliases. Browse Assay Genie's current range of PTGER2 research reagents below, or read on for the biology behind the target.
PTGER2 is a receptor for prostaglandin E2 (PGE2). Its activity is mediated by G(s) proteins, which stimulate adenylate cyclase. The resulting rise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle. This makes PTGER2 a useful node for studying how a single lipid mediator can drive cyclic nucleotide signalling at the cell surface.
The PTGER2 gene encodes a protein that belongs to the G protein-coupled receptor 1 family and is located at the cell membrane. HGNC places it in the prostaglandin receptors gene group. The protein is commonly called EP2, and the EP2 subtype name distinguishes it from other PGE2 receptors such as PTGER3. Mouse and rat each have a Ptger2 ortholog, so the receptor can be studied in common rodent models.
PGE2 is a metabolite of arachidonic acid with different biological activities in a wide range of tissues, and PTGER2 is one of the receptors through which it acts. According to the NCBI Gene summary, mutations in this gene are associated with aspirin-induced susceptibility to asthma. Earlier HGNC names for the gene were prostaglandin E receptor 2 (subtype EP2), 53kD, and the COX-2 alias is listed among its previous symbols, so it is worth checking which gene a reference refers to when searching the literature.
PTGER2 mediates responses to PGE2, an arachidonic acid metabolite with varied activities across tissues, making it a core component of prostanoid receptor studies.
As a G(s)-coupled receptor that stimulates adenylate cyclase, PTGER2 is a model for analysing receptor-driven increases in intracellular cAMP.
The cAMP rise triggered by PTGER2 produces a relaxing effect on smooth muscle, linking the receptor to studies of muscle tone.
Mutations in PTGER2 are associated with aspirin-induced susceptibility to asthma, so the receptor is relevant to research on respiratory disease.
PTGER2 is a receptor for prostaglandin E2. It couples to G(s) proteins that stimulate adenylate cyclase, increasing intracellular cAMP. This cAMP rise is responsible for the relaxing effect of the receptor on smooth muscle.
PTGER2 is also called EP2, and UniProt names the protein prostaglandin E2 receptor EP2 subtype. HGNC lists COX-2 as an alias or previous symbol, and earlier gene names included prostaglandin E receptor 2 (subtype EP2), 53kD.
Mouse and rat both carry a Ptger2 ortholog. NCBI Gene reports that mutations in the human gene are associated with aspirin-induced susceptibility to asthma. Check the datasheet of any product for its validated reactivity.
Other prostaglandin E receptors and prostanoid signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P43116; product specifications from Assay Genie datasheets.