VPS37A
VPS37A (vacuolar protein sorting-associated protein 37A, also known as HCRP1, SPG53 and PQBP2) is a component of the ESCRT-I complex, a regulator of vesicular trafficking. It is required for sorting ubiquitinated endocytic cargo into multivesicular bodies. Browse Assay Genie's current range of VPS37A research reagents below, or read on for the biology behind the target.
VPS37A is a component of the ESCRT-I (endosomal sorting complex required for transport I) complex, a regulator of vesicular trafficking. The complex is required for the sorting of ubiquitinated transmembrane proteins, including endocytic ubiquitinated cargo, into the internal vesicles of multivesicular bodies. UniProt also notes that the protein may be involved in cell growth and differentiation.
The VPS37A gene belongs to the VPS37 family and is classed by HGNC in the ESCRT-I gene group. The protein is annotated to the late endosome membrane and the nucleus. RefSeq reports that alternatively spliced transcript variants exist for this gene, and that a related pseudogene lies on chromosome 5. The mouse ortholog is Vps37a.
The gene has carried several names. Earlier names include vacuolar protein sorting 37A (yeast), vacuolar protein sorting 37 homolog A (S. cerevisiae) and polyglutamine binding protein 2, and aliases include FLJ32642, HCRP1, SPG53 and PQBP2. In disease, expression of VPS37A is downregulated in hepatocellular carcinoma, and mutations in the gene are associated with autosomal recessive spastic paraplegia-53. This makes it a useful subject for studies of endosomal sorting, cancer biology and neurological disease.
VPS37A is an ESCRT-I component needed to sort ubiquitinated endocytic cargo into multivesicular bodies.
As a regulator of vesicular trafficking, VPS37A helps researchers dissect how ESCRT-I functions within the endosomal pathway.
VPS37A expression is downregulated in hepatocellular carcinoma, making it a candidate for studies of liver cancer.
Mutations in VPS37A are associated with autosomal recessive spastic paraplegia-53, linking ESCRT-I function to neurological disease.
VPS37A is a component of the ESCRT-I complex, which regulates vesicular trafficking. It is required for sorting endocytic ubiquitinated cargo into multivesicular bodies. UniProt also notes it may be involved in cell growth and differentiation.
VPS37A is also called HCRP1, SPG53, PQBP2 and FLJ32642. Earlier names include polyglutamine binding protein 2 and vacuolar protein sorting 37 homolog A (S. cerevisiae). The HGNC name is VPS37A subunit of ESCRT-I. RefSeq reports alternatively spliced transcript variants.
Yes. Mutations in VPS37A are associated with autosomal recessive spastic paraplegia-53, and its expression is downregulated in hepatocellular carcinoma. A mouse ortholog, Vps37a, exists; check the datasheet of any product for its validated reactivity.
Other VPS family proteins, ESCRT components and endosomal trafficking targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8NEZ2; product specifications from Assay Genie datasheets.