ASGR1
ASGR1 (asialoglycoprotein receptor 1, also known as CLEC4H1) is the major subunit of the asialoglycoprotein receptor, a transmembrane C-type lectin that clears galactose- and N-acetylgalactosamine-terminated glycoproteins from the circulation by endocytosis. Browse Assay Genie's current range of ASGR1 research reagents below, or read on for the biology behind the target.
ASGR1 encodes a subunit of the asialoglycoprotein receptor, a transmembrane protein that plays a critical role in serum glycoprotein homeostasis. The receptor mediates the endocytosis and lysosomal degradation of glycoproteins that carry exposed terminal galactose or N-acetylgalactosamine residues, removing them from circulation.
The asialoglycoprotein receptor is a hetero-oligomeric protein made up of major and minor subunits encoded by different genes. The ASGR1 protein is the more abundant major subunit, and ASGR2 encodes its minor partner. UniProt lists the protein at the cell membrane and also as a secreted form. The ASGR1 gene is assigned to the C-type lectin domain containing group, and alternatively spliced transcript variants encoding multiple isoforms have been observed. Mouse and rat each have an Asgr1 ortholog.
ASGR1 is also of interest in infection and drug delivery. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses, including hepatitis B, and it is a target for liver-specific drug delivery. In a microbial infection context, UniProt notes that ASGR1 plays an essential role in ACE2-independent SARS-CoV-2 entry by acting as an alternate receptor. Researchers studying the ASGR1 gene or the ASGR1 protein therefore work across glycobiology, hepatology and virology.
ASGR1 mediates endocytosis and lysosomal degradation of glycoproteins with exposed galactose or N-acetylgalactosamine, making it central to studies of serum glycoprotein clearance.
The receptor may facilitate hepatic infection by viruses including hepatitis B, and acts as an alternate, ACE2-independent receptor for SARS-CoV-2.
The asialoglycoprotein receptor is a recognised target for liver-specific drug delivery, which drives research into ligand design and uptake.
As a member of the C-type lectin domain containing group, ASGR1 is studied for carbohydrate recognition and receptor subunit assembly.
ASGR1 is the major subunit of the asialoglycoprotein receptor. The receptor mediates endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues, which supports serum glycoprotein homeostasis. It may also facilitate hepatic viral infection and acts as an alternate SARS-CoV-2 receptor.
ASGR1 is the HGNC symbol for asialoglycoprotein receptor 1, and CLEC4H1 is a listed alias. Alternatively spliced transcript variants encoding multiple isoforms have been observed. It is the major subunit, paired with the minor subunit encoded by ASGR2 in the hetero-oligomeric receptor.
Yes. Mouse and rat both have an ortholog named Asgr1. Researchers working in these species should check the datasheet of any product for its validated reactivity. ASGR1 is also linked to hepatic viral infection and liver-targeted drug delivery in the human receptor.
The minor subunit partner of the asialoglycoprotein receptor, with further C-type lectin and glycoprotein clearance targets.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P07306; product specifications from Assay Genie datasheets.