TLL1
TLL1 (tolloid like 1) is a secreted, zinc-dependent astacin-family metalloprotease that processes procollagen C-propeptides and other precursor substrates. It is required for embryonic development and influences dorsal-ventral patterning and skeletogenesis. Browse Assay Genie's current range of TLL1 research reagents below, or read on for the biology behind the target.
TLL1, also known by its full name tolloid-like protein 1, is a protease that processes procollagen C-propeptides. Its named substrates include chordin, pro-biglycan and pro-lysyl oxidase. UniProt describes it as the predominant protease of this kind during development, where it influences dorsal-ventral patterning and skeletogenesis, and as required for embryonic development. The protein is secreted, so it acts in the extracellular space.
The TLL1 gene encodes an astacin-like, zinc-dependent metalloprotease of the peptidase M12A family. HGNC places it in the astacin gene group, and the enzyme carries the class designation EC 3.4.24.-. The human TLL1 protein is encoded on chromosome 4, and the mouse ortholog is Tll1. Alternatively spliced transcript variants encoding different isoforms have been reported for the gene.
Studies in mice suggest that TLL1 plays multiple roles in the development of the mammalian heart and is essential for formation of the interventricular septum. In humans, allelic variants of the gene are associated with atrial septal defect type 6. This combination of extracellular matrix processing, developmental patterning and congenital heart disease makes TLL1 a useful subject for researchers studying protease-driven tissue formation and cardiac development.
Mouse studies indicate TLL1 acts in several steps of heart development and is essential for forming the interventricular septum.
Allelic variants of TLL1 are associated with atrial septal defect type 6, linking the protease to septal malformation.
TLL1 processes procollagen C-propeptides and substrates such as pro-biglycan and pro-lysyl oxidase, placing it in matrix maturation pathways.
TLL1 cleaves chordin and influences dorsal-ventral patterning and skeletogenesis, and it is required for embryonic development.
TLL1 is a secreted, zinc-dependent metalloprotease that processes procollagen C-propeptides, including chordin, pro-biglycan and pro-lysyl oxidase. It is required for embryonic development and influences dorsal-ventral patterning and skeletogenesis. Check the datasheet of any product for its validated reactivity.
TLL1 stands for tolloid like 1, and UniProt names the protein tolloid-like protein 1. No alternative symbols are listed in HGNC. NCBI Gene reports that alternatively spliced transcript variants encode different isoforms of the protein.
The mouse ortholog is Tll1, and mouse studies suggest roles in heart development, including formation of the interventricular septum. In humans, allelic variants of TLL1 are associated with atrial septal defect type 6.
Astacin-family proteases, substrates and extracellular matrix targets related to TLL1 with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O43897; product specifications from Assay Genie datasheets.