S100A7
S100A7 (S100 calcium binding protein A7, also known as psoriasin 1, S100A7c and PSOR1) is a small EF-hand calcium-binding protein of the S100 family. It is overexpressed in hyperproliferative skin disease and has antimicrobial and immunomodulatory activity. Browse Assay Genie's current range of S100A7 research reagents below, or read on for the biology behind the target.
S100A7 is a member of the S100 family of proteins, which contain two EF-hand calcium-binding motifs. S100 proteins are found in the cytoplasm and/or nucleus of a wide range of cells and are involved in regulating cellular processes such as cell cycle progression and differentiation. S100A7 is recorded in UniProt as both cytoplasmic and secreted. Reported activities of the protein include antimicrobial action against bacteria and induction of immunomodulatory responses.
S100A7 differs from the other S100 proteins of known structure. One of its EF-hand motifs, at the N-terminus, has lost the ability to bind calcium. The protein is overexpressed in hyperproliferative skin diseases, which makes it a frequent subject of dermatological and epithelial biology studies. Researchers working on this target may use an S100A7 antibody or an S100A7 ELISA kit to examine its levels, although the right format depends on the question being asked.
The S100A7 gene lies within a cluster of at least 13 S100 genes on chromosome 1q21, and it belongs to the HGNC groups for S100 calcium binding proteins and EF-hand domain containing proteins. The approved name was formerly given as S100 calcium-binding protein A7 (psoriasin 1), and the aliases PSOR1 and S100A7c are still in use. The mouse gene S100a15a is listed as the ortholog. Because the family is clustered and related, it is worth considering how any S100A7 protein reagent was characterised against other S100 members.
S100A7 is overexpressed in hyperproliferative skin diseases, so it is widely studied as a marker and mediator in epidermal biology.
S100A7 shows antimicrobial activity against bacteria, which makes it relevant to studies of epithelial host defence.
The protein induces immunomodulatory activities, so it is of interest when examining how epithelial proteins influence immune responses.
S100A7 lacks calcium binding in one N-terminal EF-hand, giving a useful point of comparison within the S100 family.
S100A7 is an S100 family calcium-binding protein linked to processes such as cell cycle progression and differentiation. It shows antimicrobial activity against bacteria and induces immunomodulatory activities. It is also overexpressed in hyperproliferative skin diseases.
S100A7 is also called psoriasin 1, and the previous HGNC name was S100 calcium-binding protein A7 (psoriasin 1). Other aliases are S100A7c and PSOR1. The UniProt entry names the protein Protein S100-A7.
S100A7 belongs to the S100 family, whose genes form a cluster on chromosome 1q21. It differs from other S100 proteins of known structure because one N-terminal EF-hand cannot bind calcium. The mouse ortholog is S100a15a; check the datasheet of any product for its validated reactivity.
Other S100 family proteins and EF-hand calcium-binding proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P31151; product specifications from Assay Genie datasheets.