RANGAP1
RANGAP1 (Ran GTPase activating protein 1; also known as Fug1, KIAA1835 and SD) is a GTPase activator for RAN that associates with the nuclear pore complex. By switching RAN from its GTP-bound to its GDP-bound state, it supports the regulation of nuclear transport. Browse Assay Genie's current range of RANGAP1 research reagents below, or read on for the biology behind the target.
RANGAP1 is a GTPase activator for RAN. It converts cytoplasmic GTP-bound RAN to GDP-bound RAN, a step that is essential for RAN-mediated nuclear import and export. It also mediates the dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export. In this way the RANGAP1 protein helps keep the RAN GTPase cycle running in the direction that nuclear transport requires.
The RANGAP1 gene encodes a protein that associates with the nuclear pore complex and takes part in the regulation of nuclear transport. It interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP) binding and exchange. Alternative splicing of the gene results in multiple transcript variants. UniProt places the protein in the RNA1 family and records it in several locations: the cytoplasm, the nucleoplasm, the nuclear envelope, the kinetochore at the centromere, and the spindle.
The gene's previous HGNC name, segregation distorter homolog (Drosophila), is reflected in the alias SD, while Fug1 and KIAA1835 are further alternative names. HGNC lists RANGAP1 in the group of microRNA protein coding host genes. A mouse ortholog, Rangap1, is recorded. Researchers studying nuclear transport, the RAN cycle or the mechanics of export complexes may look to RANGAP1 antibody, RANGAP1 ELISA kit and RANGAP1 protein reagents as tools for their work.
RANGAP1 is essential for RAN-mediated nuclear import and export, making it a central component to study in transport regulation.
It converts GTP-bound RAN to GDP-bound RAN and regulates GTP binding and exchange, so it is relevant to RAN signalling research.
RANGAP1 mediates cargo dissociation from export complexes containing XPO1, RAN and RANBP2 after export.
The protein associates with the nuclear pore complex, linking it to studies of pore-associated regulation and localisation.
RANGAP1 is a GTPase activator for RAN. It converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for nuclear import and export. It also mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after export.
RANGAP1 is also called Fug1, KIAA1835 and SD. Its previous HGNC name was segregation distorter homolog (Drosophila). The full name is Ran GTPase activating protein 1. NCBI Gene notes that alternative splicing produces multiple transcript variants.
A mouse ortholog, Rangap1, is recorded for the human gene. UniProt assigns the protein to the RNA1 family. Check the datasheet of any product for its validated reactivity before planning cross-species experiments.
RAN, its export partners and other nuclear transport proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P46060; product specifications from Assay Genie datasheets.